大黄牡丹汤对穿孔性阑尾炎术后患者炎症因子的干预分析OA

Objective To analyze the effect of postoperative adjunctive therapy with Dahuang Mudan Decoction on inflammatory cytokine levels in patients with perforated appendicitis(PA)using propensity score matching(PSM).Methods A retrospective study included 312 PA patients admitted to Yancheng Third People's Hospital and Qinghai Tongde County People's Hospital between January 2020 and December 2024.Among them,253 patients received conventional postoperative anti-inflammatory treatment(control group),and 59 patients received additional Dahuang Mudan Decoction alongside conventional anti-inflammatory therapy(observation group).Propensity score matching(PSM)was applied to balance confounding factors between groups with a 1∶1 matching ratio.After matching,the following outcomes were compared:baseline characteristics;treatment efficacy;TCM syndrome scores;surgery-related indicators;inflammatory cytokine levels[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),IL-8,IL-10,IL-12P70];gastrointestinal function recovery parameters;incidence of postoperative complications.Results After PSM,56 patients in the observation group were successfully matched with 56 in the control group.On day 5 post-treatment,the total effective rate was significantly higher in the observation group(98.21%)than in the control group(87.50%)(P＜0.05).The observation group also showed significantly lower TCM syndrome scores and lower levels of TNF-α,IL-6,and IL-8(P＜0.05).Levels of IL-10 and IL-12P70 increased from baseline in both groups(P＜0.05),but the intergroup difference was not statistically significant(P＞0.05).Compared with the control group,the observation group had significantly shorter time to bowel sound recovery,first flatus,first defecation,and postoperative hospital stay(P＜0.05).There was no significant difference in the incidence of postoperative complications between the two groups(P＞0.05).Conclusion Postoperative administration of Dahuang Mudan Decoction in PA patients demonstrates favorable efficacy and safety.It significantly reduces inflammatory response,improves TCM symptoms,shortens hospital stay,and promotes postoperative recovery.Its applicability in primary hospitals suggests significant value for widespread adoption.