自拟益气调脾解毒方对重症患者贫血的疗效观察OA
Observation on the efficacy of self-designed Yiqi Tiaopi Jiedu Decoction for anemia in critically ill patients
目的 观察益气调脾解毒方治疗气虚毒滞型重症患者贫血的临床疗效.方法 选取宁夏回族自治区中西结合医院 2023 年 1 月～2024 年 12 月收住在重症医学科、重症康复科且符合纳入标准的患者 72 例,按照随机数字表法分为观察组和对照组,每组 36 例.对照组予以叶酸片 10mg日 3 次,腺苷钴胺片 1.0mg日 3 次.观察组在对照组常规西药治疗基础上加用益气调脾解毒方中药治疗,两组均治疗 3 周.监测两组治疗前及治疗后 3 周的红细胞计数(RBC)、血红蛋白(HGB)、红细胞压积(HCT)、总蛋白(TP)、白蛋白(ALB)、前白蛋白(PA)、胆碱酯酶(CHE)、肌酐(CREA)、尿素(BUN)及血尿素/肌酐比值(UCR)的变化.采用中医证候量化总积分法,分别对两组患者于治疗前后统计主要症状和体征(面色㿠白、神疲乏力、气短懒言、不思饮食、脘腹胀满、痰多、大便粘滞、肌肤甲错、舌淡暗、脉沉涩)积分比较.结果 观察组总有效 80.56%,对照组总有效 50%,观察组明显优于对照组,两组治疗总有效率比较差异具有统计学意义(P＜0.05).观察组中医症状和体征积分明显优于对照组,比较差异均具有统计学意义(P＜0.05).两组治疗后组间HGB、TP、ALB、CHE比较差异均具有统计学意义(P＜0.05).结论 益气调脾解毒方治疗气虚毒滞型重症患者贫血疗效较好,能改善中医主要症状和体征,可提升HGB,能有效改善贫血,同时提升TP、ALB及CHE,改善营养指标,值得进一步推广.
Objective To observe the clinical efficacy of Yiqi Tiaopi Jiedu Decoction(Qi-Boosting,Spleen-Regulating,Toxin-Resolving Decoction)in treating anemia in critically ill patients with the pattern of Qi deficiency and toxin stagnation.Methods A total of 72 patients were selected from the Intensive Care Unit(ICU)and Intensive Rehabilitation Unit of the Ningxia Integrated Chinese and Western Medicine Hospital.These patients were hospitalized between January 2023 and December 2024 and met the inclusion criteria.Then,they were randomly divided into an observation group and a control group using a random number table,with 36 patients in each group.The control group received folic acid tablets(10mg,three times daily)and cobamamide tablets(1.0mg,three times daily).The observation group received Yiqi Tiaopi Jiedu Decoction in addition to the conventional Western medication given to the control group.Treatment lasted for 3 weeks in both groups.Changes in the following parameters were monitored before treatment and after 3 weeks of treatment:Red blood cell count(RBC),hemoglobin(HGB),hematocrit(HCT),total protein(TP),albumin(ALB),prealbumin(PA),cholinesterase(CHE),creatinine(CREA),blood urea nitrogen(BUN),and blood urea nitrogen/creatinine ratio(UCR).Using a quantitative TCM syndrome scoring system,the total scores for main symptoms and signs(sallow complexion,mental fatigue and weakness,shortness of breath with reluctance to speak,poor appetite,epigastric and abdominal distension,excessive phlegm,sticky stool,squamous and dry skin,pale-dark tongue,deep-choppy pulse)were compared between the two groups before and after treatment.Results The total effective rate was 80.56%in the observation group and 50%in the control group.The observation group was significantly superior to the control group,and the difference in total effective rate was statistically significant(P＜0.05).The TCM symptom and sign scores in the observation group were significantly better than those in the control group,with statistically significant differences(P＜0.05).After treatment,inter-group comparisons showed statistically significant differences between the two groups for HGB,TP,ALB,and CHE(P＜0.05).Conclusion Yiqi Tiaopi Jiedu Decoction demonstrates good efficacy in treating anemia in critically ill patients with the Qi deficiency and toxin stagnation pattern.It can alleviate main TCM symptoms and signs,elevate HGB levels to effectively improve anemia,while also increasing TP,ALB,and CHE levels to improve nutritional indicators.It is worthy of further promotion.
黄封黎;钱娇;王佩佩;冯涛
宁夏回族自治区中西医结合医院,宁夏 银川 750000宁夏回族自治区中西医结合医院,宁夏 银川 750000宁夏回族自治区中西医结合医院,宁夏 银川 750000宁夏回族自治区中西医结合医院,宁夏 银川 750000
医药卫生
益气调脾解毒方气虚毒滞型重症患者贫血
Yiqi Tiaopi Jiedu DecoctionQi deficiency and toxin stagnation patternCritically ill patientsAnemia
《四川中医》 2026 (1)
63-69,7
2024年宁夏回族自治区卫生健康委科研课题(2024-NWZC-B007).
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