慢性牙周炎与口腔鳞状细胞癌相关关系的研究进展OA
Research Progress on the Relationship between Chronic Periodontitis and Oral Squamous Cell Carcinoma
慢性牙周炎(chronic periodontitis,CP)是口腔最常见慢性炎性病变之一;口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)是口腔颌面部最常见的恶性肿瘤之一,占口腔癌的90%以上,且发病率和死亡率呈年轻化上升趋势,已成为主要公共卫生问题.近年来,CP与OSCC相关关系的研究越来越受到关注,"炎-癌转化"是目前研究的热点与重点.本文主要就CP与OSCC相关关系,包括:牙周主要致病菌、炎性细胞因子以及抗炎治疗在OSCC发生、发展过程中的作用和相关调控转化机制进行综述,以期为明确CP与OSCC之间的相关关系,并寻找潜在的OSCC预防方法及治疗靶点提供一定的理论依据.
Chronic periodontitis(CP)is a highly prevalent oral inflammatory disease,while oral squamous cell carcino-ma(OSCC)represents the most common oral malignancy,accounting for over 90%of all oral cancer cases.OSCC incidence and mortality are on the rise in younger age groups.This trend poses a significant public health challenge.Recent years have witnessed growing interest in the relationship between CP and OSCC,with the"inflammation-cancer transformation"being a major focus and research priority.This article reviews the relationship between CP and OSCC,focusing on the roles and re-lated regulatory mechanisms of major periodontal pathogens,inflammatory cytokines,and anti-inflammatory therapy in the occurrence and development of OSCC.This review aims to clarify the association between CP and OSCC and to provide a the-oretical basis for exploring potential preventive and therapeutic strategies against OSCC.
杨秋华;张也;唐婉蓉
641400 成都,简阳市人民医院 口腔科641400 成都,简阳市人民医院 口腔科641400 成都,简阳市人民医院 口腔科
医药卫生
慢性牙周炎牙周致病菌炎性细胞因子口腔鳞状细胞癌发病机制研究进展
Chronic periodontitisPeriodontal pathogenic bacteriaInflammatory cytokinesOral squamous cell carcinomaPathogenesisResearch progress
《肿瘤预防与治疗》 2026 (2)
153-159,7
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