靶向三阴性乳腺癌中血管生成拟态的临床意义OA
Clinical Implications of Targeting Vasculogenic Mimicry in Triple-Nega-tive Breast Cancer
三阴性乳腺癌(triple negative breast cancer,TNBC)因其侵袭性转移而成为临床治疗难点.肿瘤中的血管能帮助肿瘤转移,传统的血管靶向药物虽已应用到临床中,但对 TNBC的效果不佳.血管生成拟态(vasculogenic mimicry,VM)被指出是TNBC侵袭转移的关键之一.近年来研究表明VM的形成涉及一系列复杂机制并通过多种信号通路发挥调控作用,陆续有研究者提出针对VM的TNBC的治疗方法,也已有部分药物进入临床研究.本文概述了VM在TNBC中的重要性,并探讨了针对VM的临床治疗策略.
Triple-negative breast cancer(TNBC)poses a significant clinical challenge due to its invasive and metastatic nature.Blood vessels within tumors promote metastasis.However,traditional vascular-targeting agents have proven largely ineffective in treating TNBC.Vasculogenic mimicry(VM)has been identified as a key driver of invasion and metastasis in TNBC.Recent studies have revealed that the formation of VM involves complex mechanisms regulated by multiple signaling pathways.Additionally,therapeutic strategies targeting VM in TNBC have been proposed,with several candidate drugs hav-ing entered clinical trials.This paper outlines the importance of VM in TNBC and explores VM-targeted clinical treatment strategies.
甘雨鑫;米坤;刘惠芬
610041 成都,电子科技大学 医学院610041 成都,四川省肿瘤医院·研究所,四川省肿瘤临床医学研究中心,四川省癌症防治中心,电子科技大学附属肿瘤医院 实验研究部610041 成都,四川省肿瘤医院·研究所,四川省肿瘤临床医学研究中心,四川省癌症防治中心,电子科技大学附属肿瘤医院 实验研究部
医药卫生
三阴性乳腺癌血管生成拟态侵袭转移治疗靶点
Triple-negative breast cancerVasculogenic mimicryInvasion and metastasisTherapeutic target
《肿瘤预防与治疗》 2026 (2)
142-146,5
This study was supported by Natural and Science Foundation of Sichuan Province(No.2024NSFSC0741,No.2025ZNSFSC0563). 四川省自然科学基金(编号:2024NSFSC0741、2025ZNSFSC0563)
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