靶向脂肪酸代谢重塑肿瘤免疫微环境:机制与免疫治疗新策略OA

The development and progression of tumors are closely associated with the interactions of multiple factors with-in their microenvironment,where fatty acid metabolism plays a pivotal role.Accumulating evidence indicates that fatty acids not only supply bioenergy and biosynthetic precursors for tumor cell proliferation and metastasis,but also regulate the func-tional states and phenotypic polarization of immune cells,thereby reshaping the immunosuppressive tumor immune microenvi-ronment(TIME).Particularly,fatty acid metabolism and its derivatives are now central to research on tumor immune eva-sion and resistance mechanisms.However,the relationship between fatty acid metabolism and TIME remains poorly under-stood,especially regarding the exploration of combined therapies targeting both metabolism and immunity.This study aims to analyze how fatty acid metabolism influences tumor immune responses by modulating immune cell function and modifying TIME.It summarizes current research advancements and potential therapeutic strategies,providing theoretical foundations for developing novel immunotherapy approaches.