肺移植术后闭塞性细支气管炎的研究进展OA
Research progress on bronchiolitis obliterans syndrome after lung transplantation
肺移植(lung transplantation,LTx)是治疗终末期肺病的有效手段,可显著延长患者生存时间并改善生活质量.然而,闭塞性细支气管炎综合征(bronchiolitis obliterans syndrome,BOS)作为LTx术后常见的慢性排斥反应之一,严重影响患者长期生存.因此,对BOS的早期诊断和综合治疗是改善预后的关键,需进一步探索个体化治疗策略以优化临床管理.文章围绕BOS的临床表现、诊断方法、发病机制、危险因素、防治策略及预后特点进行综述,旨在为其临床诊治提供参考依据,为未来研究提供方向.
Lung transplantation(LTx)is an effective treatment for end-stage lung disease,significantly prolonging patient survival and improving quality of life.However,bronchiolitis obliterans syndrome(BOS),which represents a frequent manifestation of chronic rejection following LTx,significantly compromises long-term patient survival.Consequently,early diagnosis and comprehensive treatment are crucial for improving prognosis,while exploration of individualized therapeutic strategies is needed to optimize clinical management.This review comprehensively examines the clinical manifestations,diagnostic approaches,pathogenesis,risk factors,therapeutic strategies,and prognostic characteristics of BOS,aiming to provide evidence-based guidance for clinical management and future research directions.
乔烨甜;李小杉;吴波
南京医科大学无锡医学中心,南京医科大学附属无锡人民医院(无锡市人民医院)肺移植中心,江苏 无锡 214023南京医科大学无锡医学中心,南京医科大学附属无锡人民医院(无锡市人民医院)肺移植中心,江苏 无锡 214023南京医科大学无锡医学中心,南京医科大学附属无锡人民医院(无锡市人民医院)肺移植中心,江苏 无锡 214023
医药卫生
肺移植闭塞性细支气管炎综合征慢性排斥反应
lung transplantationbronchiolitis obliterans syndromechronic allograft dysfunction
《南京医科大学学报（自然科学版）》 2026 (2)
299-308,10
无锡市"双百"中青年医疗卫生拔尖人才项目(BJ2023016)无锡市人民医院雁阵人才项目(2024-YZ-KDTR-WB-2024)
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