648例皮肤恶性肿瘤疾病谱分析OA

Objective To investigate the clinical and pathological characteristics of cutaneous malignancies in the population of South China.Methods A total of 648 patients with histologi-cally confirmed cutaneous malignancies who visited the Dermatology Hospital of Southern Medical University between January 2020 and July 2023 were retrospectively analyzed.Clinical features and treatment patterns were summarized.Results Among the 648 patients(male-to-female ratio:1.25∶1),squamous cell carcinoma(31.94%)and basal cell carcinoma(31.17%)were the most common malignancies,followed by cutaneous lymphomas(13.89%),dendritic cell and his-tiocytic tumors(13.27%),and melanoma(9.72%).The distribution of tumor types differed significantly between sexes(P=0.014).Patients aged≥60 years accounted for the largest pro-portion(53.55%).Basal cell carcinoma and squamous cell carcinoma predominantly involved the head and face(91.10%and 48.79%,respectively).Melanoma mainly presented as the ac-ral subtype(79.37%),while cutaneous lymphomas most often affected the trunk and extremities(62.22%).Nodular-type basal cell carcinoma was the most common histologic subtype(74.75%),with 78.22%classified as low-risk.In squamous cell carcinoma,invasive disease accounted for 91.79%.Female predominance was observed in melanoma(63.49%),with Clark level IV and Breslow thickness≤1 mm being the most frequent.Cutaneous lymphomas were mainly of T/NK-cell origin(93.33%),with mycosis fungoides being the most common subtype(59.52%).Among dendritic cell and histiocytic tumors,xanthogranuloma predominated(82.56%).Surgical excision was the primary treatment modality for basal cell carcinoma and squamous cell carcinoma(95.54%and 95.17%,respectively).Conclusions In South China,squamous cell carcinoma and basal cell carcinoma are the most prevalent cutaneous malignancies,with elderly individuals and sun-exposed head and face regions representing high-risk groups.Mel-anoma is predominantly acral and more common in women,whereas cutaneous lymphomas occur relatively more frequently in younger patients and are mainly of T/NK-cell origin.These regional and age-related patterns provide important implications for precision diagnosis,risk assessment,and tailored management strategies for cutaneous malignancies.