参蛤定喘方对COPD合并肺动脉高压患者心肺功能及炎症因子的影响OA

Objective To analyze the effects of Shenge Dingchuan formula on the cardiopulmonary function and inflammatory factors in patients with chronic obstructive pulmonary disease(COPD)complicated with pulmonary hypertension(PAH).Methods A total of 96 patients with stable COPD complicated with PAH who were admitted to the hospital from January 2022 to October 2024 were selected as the research subjects.They were divided into the control group and the experimental group by random number table method,with 48 cases in each group.The control group was given conventional anti-infection treatment,while the experi-mental group was treated with the modified Shenge Dingchuan formula in addition to the treatment of the con-trol group.The clinical efficacy and traditional Chinese medicine syndrome scores,cardiac,pulmonary function indicators and inflammatory factor levels of the two groups before and after treatment were compared,and the safety of the two groups was evaluated.Results After treatment,the traditional Chinese medicine main symp-tom scores,secondary symptom scores and total scores of two groups were lower than those before treatment,and those of the experimental group were lower than those of the control group,with statistically significant differences(P<0.05).The total effective rate of the experimental group was higher than that of the control group(P<0.05).After treatment,the forced vital capacity(FVC),forced expiratory volume in one second(FEV1),and FEV1/FVC of two groups were higher than those before treatment,and those of the experimen-tal group were higher than those of the control group,with statistically significant differences(P<0.05).Af-ter treatment,the pulmonary artery systolic pressure,serum interleukin-6,high-sensitivity C-reactive protein and tumor necrosis factor-α levels of two groups were lower than those before treatment,and those of the ex-perimental group were lower than those of the control group,with statistically significant differences(P<0.05).After treatment,the right ventricular ejection fraction of two groups was higher than that before treat-ment,and that of the experimental group was higher than that of the control group,and the 6 min walking dis-tance was longer than that before treatment,and that of the experimental group was longer than that of the control group,with statistically significant differences(P<0.05).After treatment,the right ventricular end-diastolic diameter of both groups was shorter than that before treatment,and that of the experimental group was shorter than that of the control group,with statistically significant differences(P<0.05).There was no statistically significant difference in the occurrence of adverse reactions between the two groups(P>0.05).Conclusion Shenge Dingchuan formula can effectively improve the cardiopulmonary function of patients with COPD and PAH,inhibit inflammatory responses,improve clinical efficacy and have good safety.