特殊口腔异位定植菌与慢性肝病的关系OA
Association between ectopically colonized oral bacteria and chronic liver disease
慢性肝病是多种肝脏疾病的总称,其患病率呈逐年上升趋势.随着疾病进展,患者可出现多种严重并发症,甚至发展为肝衰竭.近年来,多项研究揭示了异位定植菌与慢性肝病的关系,探讨了异位定植菌在慢性肝病诊断及治疗等方面的潜在价值.本文系统综述了特殊异位定植菌与代谢相关脂肪性肝病、肝硬化和肝癌之间的关系,解析异位定植菌影响慢性肝病的相关机制,为利用异位定植菌对慢性肝病进行诊治提供参考.
Chronic liver disease is a general term for a variety of liver diseases,and its prevalence rate is increasing year by year.With the progression of the disease,patients may experience a variety of serious complications and even progress to liver failure.In recent years,a number of studies have revealed the association between ectopically colonized oral bacteria and chronic liver disease and explored their potential value in the diagnosis and treatment of chronic liver disease.This article systematically reviews the association of ectopically colonized oral bacteria with metabolic associated fatty liver disease,liver cirrhosis,and liver cancer and analyzes the mechanism for the influence of ectopically colonized oral bacteria on chronic liver disease,so as to provide a reference for the diagnosis and treatment of chronic liver disease using ectopically colonized oral bacteria.
贺靖淋;卢晨霞;李晓东
湖北中医药大学中医学院,武汉 430065湖北省中医院肝病研究所,中医肝肾研究及应用湖北省重点实验室,中医肝病临床研究中心,武汉 430061||中国中医科学院广安门医院代谢病研究所,北京 100053湖北省中医院肝病研究所,中医肝肾研究及应用湖北省重点实验室,中医肝病临床研究中心,武汉 430061||湖北中医药大学附属医院,武汉 430061
异位定植菌代谢相关脂肪性肝病肝硬化肝肿瘤
Ectopic Colonizing BacteriaMetabolic Dysfunction-Associated Fatty Liver DiseaseLiver CirrhosisLiver Neoplasms
《临床肝胆病杂志》 2026 (1)
235-240,6
国家自然科学基金面上项目(82274352)湖北省自然科学基金(2020CFA023,2023AFB426,2023AFD129,2023AFD178) National Natural Science Foundation of China(General Program)(82274352)Natural Science Foundation of Hubei Province(2020CFA023,2023AFB426,2023AFD129,2023AFD178)
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