创伤性颅脑损伤患者血清VILIP-1、ADAMTS13、FGL2表达与病情严重程度和预后的关系OA
Relationships among serum VILIP-1,ADAMTS13,FGL2 expression and severity and prognosis of traumatic brain injury patients
目的 探讨创伤性颅脑损伤(TBI)患者血清视锥蛋白样蛋白-1(VILIP-1)、血管性血友病因子裂解酶13(ADAMTS13)、纤维蛋白原样蛋白2(FGL2)表达与病情严重程度和预后的关系.方法 纳入 2021年5 月—2024 年5 月内江市第一人民医院急诊科收治的 165 例TBI患者作为创伤组,按格拉斯哥昏迷指数GCS评分为轻度(65 例)、中度(57 例)、重度(43 例),并选取同期100 例健康体检者作为对照组.使用ELISA法检测受试者血清中VILIP-1、ADAMTS13、FGL2 的水平;采用Logistic多因素分析影响TBI患者预后情况的因素;使用ROC曲线分析VILIP-1、ADAMTS13、FGL2 水平对TBI患者预后情况的预测价值.结果 TBI患者血清中VILIP-1、FGL2 水平高于对照组,重度组>中度组>轻度组(P<0.05);TBI患者血清中ADAMTS13 水平低于对照组,重度组<中度组<轻度组(P<0.05).血清VILIP-1、FGL2 水平预后不良组高于预后良好组,ADAMTS13 水平低于预后良好组,均具有统计学意义(P<0.05).VILIP-1(OR=2.913,95%CI:1.499～5.661)、FGL2(OR=2.241,95%CI:1.325～3.789)是影响 TBI 患者预后的危险因素,ADAMTS13(OR=0.835,95%CI:0.744～0.937)是影响TBI患者预后的保护因素(P<0.05).血清VILIP-1、ADAMTS13、FGL2以及联合预测TBI患者预后情况的AUC分别为 0.772、0.765、0.861 和 0.937,联合预测优于各自单独预测(Z联合-VILIP-1=4.671、Z联合-ADAMTS13=4.522、Z联合-FGL2=3.328,P<0.05).结论 血清 VILIP-1、FGL2 升高和ADAMTS13 降低与TBI病情及预后显著相关,联合检测可有效预测预后.
Objective To investigate the relationships among the expression of serum visinin-like protein 1(VILIP-1),a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13(ADAMTS13),and fibrinogen like protein 2(FGL2)in patients with traumatic brain injury(TBI)and the severity of the disease and prognosis.Methods A total of 165 TBI patients in the Department of Emergency,the First People's Hospital of Neijiang from May 2021 to May 2024 were enrolled as the trauma group,which were divided into mild(65 cases),moderate(57 cases)and severe(43 cases)according to GCS,and 100 healthy subjects were selected as the control group during the same period.ELISA method was applied to detect the levels of VILIP-1,ADAMTS13,and FGL2 in the serum of subjects.Logistic multiple factors were applied to analyze the factors affecting the prognosis of TBI patients.Receiver operating characteristic(ROC)curve was applied to analyze the predictive value of VILIP-1,ADAMTS13,and FGL2 levels for the prognosis of TBI patients.Results The levels of VILIP-1 and FGL2 in the serum of TBI patients were prominently higher than those in the control group,severe group>moderate group>mild group(P<0.05).The level of ADAMTS13 in the serum of TBI patients was prominently lower than that of the control group,severe group<moderate group<mild group(P<0.05).The serum levels of VILIP-1 and FGL2 in the poor prognosis group were prominently higher than those in the good prognosis group,and the level of ADAMTS13 was prominently lower than that in the good prognosis group(P<0.05).VILIP-1(OR=2.913,95%CI=1.499-5.661)and FGL2(OR=2.241,95%CI=1.325-3.789)were risk factors affecting the prognosis of TBI patients,while ADAMTS13(OR=0.835,95%CI=0.744-0.937)was a protective factor affecting the prognosis of TBI patients(P<0.05).The area under curve(AUC)values of serum VILIP-1,ADAMTS13,FGL2,and their combined prediction for the prognosis of TBI patients were 0.772,0.765,0.861,and 0.937,respectively.The combined prediction was superior to their individual predictions(Zcombination-VILIP-1=4.671,Zcombination-ADAMTS13=4.522,Zcombination-FGL2=3.328,P<0.05).Conclusions The increase of VILIP-1 and FGL2 and the decrease of ADAMTS13 are significantly associated with the condition and prognosis of TBI,and the combined detection can effectively predict the prognosis.
徐鉴;余秋燕;伯东
641000 内江,内江市第一人民医院急诊科641000 内江,内江市第一人民医院急诊科641000 内江,内江市第一人民医院急诊科
医药卫生
创伤性颅脑损伤视锥蛋白样蛋白-1血管性血友病因子裂解酶13纤维蛋白原样蛋白2严重程度预后
traumatic brain injuryvisinin-like protein 1a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13fibrinogen like protein 2severity of diseaseprognosis
《临床神经外科杂志》 2026 (1)
19-24,6
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