细胞焦亡在肝纤维化中的作用及研究进展OA

Hepatic fibrosis is not only a pathological process of hepatic self-repair after chronic liver injury,but also a critical stage in the progression of chronic liver disease to liver cirrhosis.Studies have shown that as a pro-inflammatory form of programmed cell death,pyroptosis plays an important role in various diseases and is also considered a potential therapeutic target for hepatic fibrosis.This article systematically reviews the association of pyroptosis in hepatocytes,hepatic stellate cells,and hepatic macrophages with hepatic fibrosis and discusses pyroptosis-mediated therapeutic strategies targeting hepatic fibrosis.