阿司匹林在代谢相关脂肪性肝病中的作用OA
Role of aspirin in metabolic associated fatty liver disease
代谢相关脂肪性肝病(MAFLD)是全球慢性肝病的主要类型,其发病率持续上升且呈年轻化趋势.目前,MAFLD的治疗方案主要依赖于生活方式干预及代谢合并症的管理,尚缺乏针对MAFLD本身的有效药物.阿司匹林作为一种经典的水杨酸类非甾体抗炎药,可通过调节脂质代谢、改善胰岛素抵抗、减轻肝脏炎症与氧化应激反应、抗肝纤维化及抑制肝细胞癌等多种作用机制,干预MAFLD的病理进程,具有预防疾病发生及延缓、逆转病情进展的价值.本文系统综述了阿司匹林在MAFLD治疗中的作用机制及安全性,以期为MAFLD患者提供更多的药物治疗选择.
Metabolic associated fatty liver disease(MAFLD)is the main type of chronic liver disease in the world,with an increasingly higher incidence rate and a younger age of onset.At present,the treatment of MAFLD mainly depends on lifestyle intervention and comorbidity management,and there is still a lack of effective drugs for MAFLD itself.As a classic nonsteroidal anti-inflammatory drug of the salicylic acid family,aspirin can intervene in the pathological process of MAFLD by regulating lipid metabolism,relieving insulin resistance,reducing liver inflammation and oxidative stress response,exerting an anti-liver fibrosis effect,and inhibiting hepatocellular carcinoma,and therefore,it has the value of preventing disease onset,delaying disease progression,and reversing disease condition.This article systematically reviews the mechanism of action and safety of aspirin in the treatment of MAFLD,in order to provide more drug treatment options for MAFLD patients.
李永琪;李妍秋;孙丽娜;王超冉;冯颖;王亮;王宪波
首都医科大学附属北京地坛医院中西医结合中心,北京 100015首都医科大学附属北京地坛医院中西医结合中心,北京 100015首都医科大学附属北京地坛医院中西医结合中心,北京 100015首都医科大学附属北京地坛医院中西医结合中心,北京 100015首都医科大学附属北京地坛医院中西医结合中心,北京 100015首都医科大学附属北京世纪坛医院中医科,北京 100038首都医科大学附属北京地坛医院中西医结合中心,北京 100015
代谢相关脂肪性肝病阿司匹林药物疗法
Metabolic Associated Fatty Liver DiseaseAspirinDrug Therapy
《临床肝胆病杂志》 2026 (1)
178-182,5
国家自然科学基金(82474419)国家中医药管理局高水平中医药重点学科建设项目(zyyzdxk-2023005)首都卫生发展科研专项(2024-1-2173) National Natural Science Foundation of China(82474419)National Administration of Traditional Chinese Medicine High Level Key Discipline Construction Project of Traditional Chinese Medicine(zyyzdxk-2023005)Capital's Funds for Health Improvement and Research(2024-1-2173)
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