清肝汤联合舒肝宁治疗慢性乙型肝炎疗效评价OA
Evaluation of Therapeutic Efficacy of Qinggan Decoction Combined with Shuganning in the Treatment of Chronic Hepatitis B
目的:探讨清肝汤联合舒肝宁治疗慢性乙型肝炎的临床疗效.方法:选取 2021 年 1 月—2024 年 6 月安义县中医院收治的 100 例慢性乙型肝炎患者,随机分为观察组(清肝汤联合舒肝宁治疗)和对照组(舒肝宁治疗),各 50 例,治疗 1 个月,比较 2 组临床疗效、中医证候积分、肝功能、乙肝病毒标志物、超声指标及不良反应.结果:观察组总有效率高于对照组(94.00%vs 74.00%,P<0.01);中医证候积分、ALT、AST、TBIL、HBV-DNA、HBsAg、HBeAg 及肝脏硬度值(LSM)均低于对照组(P<0.01);2 组不良反应发生率差异无统计学意义(P>0.05).结论:清肝汤联合舒肝宁可提高治疗慢性乙型肝炎的疗效,改善症状及肝功能,安全性良好,值得推广.
Objective:To investigate the clinical efficacy of Qinggan Decoction combined with Shuganning in the treatment of chronic hepatitis B.Methods:This study enrolled 100 patients with chronic hepatitis B admitted to Anyi County Hospital of Traditional Chinese Medicine between January 2021 and June 2024 were randomly divided into study group(treated with Qinggan Decoction combined with Shuganning)and control group(treated with Shuganning alone),50 cases in each group.After 1 month of treatment,clinical efficacy,TCM symptom scores,liver function,hepatitis B viral markers,ultrasound indices and adverse reactions were compared.Results:A significantly higher total effective rate was observed in the study group compared to the control group(94.00%vs 74.00%,P<0.01).TCM symptom scores,ALT,AST,TBIL,HBV-DNA,HBsAg,HBeAg and liver stiffness measurement(LSM)in the study group were lower than those in the control group(P<0.01).There was no significant difference in adverse reaction rate(P>0.05).Conclusion:Shen's Qinggan Decoction combined with Shuganning can improve efficacy,relieve symptoms and liver function with good safety,which is worthy of promotion.
沈长龙;胡传旺;黄江华;胡泽盟;帅培;聂秋兰
安义县中医院 江西 安义 330500安义县中医院 江西 安义 330500安义县中医院 江西 安义 330500安义县中医院 江西 安义 330500安义县中医院 江西 安义 330500南昌大学附属感染病医院 南昌 330002
医药卫生
慢性乙型肝炎清肝汤乙型肝炎病毒肝功能湿热并重型
Chronic Hepatitis BShen's Qinggan DecoctionHepatitis B VirusLiver FunctionDampness-Heat Excess Syndrome
《江西中医药大学学报》 2026 (1)
46-50,5
江西省中医药管理局科技计划项目(2022B648).
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