首页|期刊导航|检验医学与临床|血小板在卵巢癌诊断、治疗和预后中的研究进展

血小板在卵巢癌诊断、治疗和预后中的研究进展OA

Research progress of platelets in the diagnosis,treatment and prognosis of ovarian cancer

中文摘要英文摘要

卵巢癌的病死率在妇科恶性肿瘤中居于首位,严重影响患者的生存质量,是临床的一大难题.血小板可在促进卵巢癌生长、协助卵巢癌转移和调控肿瘤微环境中起到重要作用,临床中可通过检测血小板计数或联合糖类抗原CA125提升卵巢癌诊断的准确度,故靶向调控血小板或血小板相关因子及其受体,可抑制卵巢癌细胞增殖,削弱肿瘤细胞的侵袭和转移能力,起到治疗效果.该文综述了血小板在卵巢癌诊断、治疗和预后中的研究进展,未来的研究可聚焦于抗血小板治疗联合化学疗法或免疫疗法等,探讨抗血小板治疗在卵巢癌中的具体疗效和机制,验证靶向血小板治疗的可行性,以期为临床制订科学可行的个性化治疗方案.

The mortality rate of ovarian cancer ranks first among gynecological malignant tumors,serious-ly affecting the quality of life of patients and posing a major clinical challenge.Platelets play a significant role in promoting the growth of ovarian cancer,assisting its metastasis,and regulating the tumor microenviron-ment.In clinical practice,the accuracy of ovarian cancer diagnosis can be enhanced by detecting platelet counts or combining them with CA125.Therefore,targeted regulation of platelets or platelet-related factors and their receptors can inhibit the proliferation of ovarian cancer cells,weaken the invasion and metastasis ability of tumor cells,and achieve therapeutic effects.This article reviews the research progress of platelets in the diag-nosis,treatment and prognosis of ovarian cancer.Future research can focus on anti-platelet therapy combined with chemotherapy or immunotherapy,to explore the specific efficacy and mechanism of anti-platelet therapy in ovarian cancer,and verify the feasibility of targeted platelet therapy,with the aim of formulating scientific and feasible personalized treatment plans for clinical practice.

梁铭阁;艾雯霞;亓丁;田欣雨;刘彩玲;李娜;刘丽

黑龙江中医药大学研究生院,黑龙江 哈尔滨 150040黑龙江中医药大学研究生院,黑龙江 哈尔滨 150040||黑龙江中医药大学附属第一医院宫腔镜室,黑龙江 哈尔滨 150040黑龙江中医药大学研究生院,黑龙江 哈尔滨 150040黑龙江中医药大学研究生院,黑龙江 哈尔滨 150040黑龙江中医药大学研究生院,黑龙江 哈尔滨 150040哈尔滨医科大学附属第六医院中医科,黑龙江 哈尔滨 150000黑龙江中医药大学附属第一医院宫腔镜室,黑龙江 哈尔滨 150040

医药卫生

血小板卵巢癌诊断依据肿瘤微环境抗癌治疗

plateletovarian cancerdiagnostic basistumor microenvironmentanti-cancer therapy

《检验医学与临床》 2026 (3)

415-420,427,7

黑龙江省中医药科研项目(ZHY2024138)黑龙江省博士后面上项目(LBH-Z24287).

10.3969/j.issn.1672-9455.2026.03.021

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