血清CA50、CA-242水平与结直肠癌患者发生淋巴结转移的关系OA
Serum CA50 and CA-242 levels and the relationship with lymph node metastasis in patients with colorectal cancer
目的 探讨血清碳水化合物抗原(CA50)、糖类抗原242(CA-242)水平与结直肠癌(CRC)患者发生淋巴结转移的关系.方法 选取2022年7月至2024年7月该院接收的160例CRC患者作为研究对象,根据是否发生淋巴结转移将其分为淋巴结转移组(72例)和淋巴结未转移组(88例).采用酶联免疫吸附试验检测患者血清CA50、CA-242水平.采用多因素Logistic回归分析CRC患者发生淋巴结转移的影响因素.绘制受试者工作特征(ROC)曲线分析血清CA50、CA-242对CRC患者发生淋巴结转移的诊断价值.结果 淋巴结转移组TNM分期为Ⅲ～Ⅳ期、肿瘤低分化、肿瘤最大径≥4.0 cm的患者比例,以及血清CA50、CA-242水平高于淋巴结未转移组,差异均有统计学意义(P<0.05).TNM分期为Ⅲ～Ⅳ期、低分化患者血清CA50、CA-242水平高于TNM分期为Ⅰ～Ⅱ期、中高分化患者,差异均有统计学意义(P<0.05).多因素Logistic回归分析结果显示,血清CA50、CA-242水平升高是CRC患者发生淋巴结转移的危险因素(P<0.05).ROC曲线分析结果显示,2项指标联合诊断CRC患者发生淋巴结转移的曲线下面积(AUC)为0.931,大于CA50和CA-242单独诊断的AUC(Z=3.489、2.951,均P<0.05).结论 CRC合并淋巴结转移患者血清CA50和CA-242水平均升高,血清CA50、CA-242联合可作为诊断CRC患者发生淋巴结转移的生物标志物.
Objective To explore the relationship between serum carbohydrate antigen(CA50)and carbo-hydrate antigen 242(CA-242)levels and lymph node metastasis in patients with colorectal cancer(CRC).Methods A total of 160 CRC patients admitted to the hospital from July 2022 to July 2024 were selected as the research subjects.They were divided into the lymph node metastasis group(72 cases)and the lymph node non-metastasis group(88 cases)based on whether lymph node metastasis occurred.The serum CA50 and CA-242 levels of the patients were detected by enzyme-linked immunosorbent assay.Multivariable Logistic regres-sion analysis was used to analyze the influencing factors of lymph node metastasis in CRC patients.The diag-nostic value of serum CA50 and CA-242 for lymph node metastasis in CRC patients was analyzed by drawing the receiver operating characteristic(ROC)curve.Results The proportions of patients with TNM stage Ⅲ-Ⅳ,poorly differentiated tumors,and tumor maximum diameter≥4.0 cm and the serum CA50 and CA-242 levels in the lymph node metastasis group were higher than those in the lymph node non-metastasis group,with statistically significant differences(P<0.05).The serum CA50 and CA-242 levels were higher in pa-tients with TNM stage Ⅲ-Ⅳ and poorly differentiated tumors than in those with TNM stage Ⅰ-Ⅱ and mod-erately to highly differentiated tumors,with statistically significant differences(P<0.05).The results of multivariable Logistic regression analysis showed that elevated serum CA50 and CA-242 levels were risk fac-tors for lymph node metastasis in CRC patients(P<0.05).The results of ROC curve analysis showed that the area under the curve(AUC)of the combined diagnosis of the two indicators for lymph node metastasis in CRC patients was 0.931,which was larger than the AUC of CA50 and CA-242 alone(Z=3.489,2.951,both P<0.05).Conclusion The serum CA50 and CA-242 levels are elevated in CRC patients with lymph node metastasis,and the combination of serum CA50 and CA-242 can be used as a biomarker for diagnosing lymph node metastasis in CRC patients.
黄炳红;邵远江;邵宏娅;庄小军
四川省广汉市人民医院:检验科,四川广汉 618300四川省广汉市人民医院:检验科,四川广汉 618300四川省广汉市人民医院:检验科,四川广汉 618300四川省广汉市人民医院:胃肠外科,四川广汉 618300
医药卫生
碳水化合物抗原糖类抗原242结直肠癌淋巴结转移
carbohydrate antigencarbohydrate antigen 242colorectal cancerlymph node
《检验医学与临床》 2026 (3)
366-370,5
四川省医学科研课题计划项目(S23WS1030).
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