ERCP+EST与ESPBD治疗肝硬化合并胆总管结石的临床对照研究OA

Objective To investigate the clinical efficacy of endoscopic retrograde cholangiopancreatogra-phy(ERCP)+endoscopic sphincterotomy(EST)and endoscopic sphincterotomy combined with balloon dila-tion(ESPBD)in the treatment of patients with liver cirrhosis(LC)complicated with common bile duct stones(CBDS).Methods A total of 167 patients with LC combined with CBDS admitted to the Third People's Hos-pital of Hengshui from January 2021 to June 2024 were selected as the research objects.According to different surgical methods,they were divided into EST group(treated with ERCP+EST,85 cases)and ESPBD group(treated with ESPBD,82 cases).The perioperative indicators(operation time,intraoperative blood loss,anal exhaust time,hospitalization time and one-time stone clearance rate),liver function indicators[aspartate amin-otransferase(AST),alanine aminotransferase(ALT),total bilirubin(TBIL)],inflammatory factors[inter-leukin-6(IL-6),C-reactive protein(CRP)]and complications were compared between the two groups.Results The one-time stone clearance rate of ESPBD group was higher than that of EST group(P<0.05).The levels of AST,ALT and TBIL in the two groups after operation were lower than those before operation,and the differences were statistically significant(P<0.05).The levels of IL-6 and CRP in the two groups af-ter operation were lower than those before operation,and the levels of IL-6 and CRP in the ESPBD group were lower than those in the EST group,and the differences were statistically significant(P<0.05).The incidence of complications in the ESPBD group was lower than that in the EST group(P<0.05).Conclusion ERCP combined with EST and ESPBD can effectively improve the perioperative indicators and liver function of pa-tients,and ESPBD can better reduce the level of inflammation and reduce the incidence of complications.