慢性肾脏病患者CRRT后发生血脂异常的影响因素OA

Objective To analyze the influencing factors for the development of dyslipidemia in patients with chronic kidney disease(CKD)after continuous renal replacement therapy(CRRT).Methods A total of 305 patients with CKD who received CRRT in this hospital from March 2023 to December 2024 were selected as the research objects.According to whether dyslipidemia occurred after CRRT,they were divided into dyslip-idemia group and normal blood lipid group.The clinical data of the two groups were compared.Multivariable Logistic regression was used to analyze the influencing factors for the development of dyslipidemia in CKD pa-tients after CRRT.Pearson correlation analysis was used to analyze the correlation between blood lipid indexes and lipoprotein a,free fatty acid(FFA),homocysteine(Hcy),serum uric acid,interleukin-1β(IL-1β)and al-bumin(Alb)levels in dyslipidemia group.Results Among 305 CKD patients after CRRT,90 patients had dyslipidemia,215 patients did not have dyslipidemia,and the incidence of dyslipidemia was 29.51%.The age,proportion of hypertension,diabetes,smoking history and serum lipoprotein a,cystatin C(Cys-C),FFA,Hcy,blood uric acid and IL-1β levels before the first dialysis in the dyslipidemia group were higher than those in the normal blood lipid group,and the differences were statistically significant(P<0.05).The levels of glomerular filtration rate(eGFR),hemoglobin(Hb)and serum Alb in the dyslipidemia group were lower than those in the normal blood lipid group,and the differences were statistically significant(P<0.05).Pearson correlation analysis showed that the levels of cholesterol(TC),triglyceride(TG)and low-density lipoprotein cholesterol(LDL-C)in the dyslipidemia group were positively correlated with the levels of lipoprotein a and Hcy(P<0.05),and negatively correlated with the level of Alb(P<0.05).TC and LDL-C levels were positively corre-lated with FFA and IL-1β levels in dyslipidemia group(P<0.05).The level of high-density lipoprotein cho-lesterol(HDL-C)in dyslipidemia group was negatively correlated with the levels of lipoprotein a,FFA,Hcy,uric acid and IL-1β(P<0.05),and positively correlated with the level of Alb(P<0.05).LDL-C level was positively correlated with serum uric acid level in dyslipidemia group(P<0.05).Multivariable Logistic re-gression analysis showed that increased age,smoking history,and increased levels of lipoprotein a,FFA and Hcy were risk factors for the development of dyslipidemia in CKD patients after CRRT(P<0.05),and in-creased level of Alb was a protective factor for the development of dyslipidemia in CKD patients after CRRT(P<0.05).Conclusion The incidence of dyslipidemia in CKD patients after CRRT is high.Age,smoking his-tory,lipoprotein a,FFA,Hcy,Alb are the influencing factors for the development of dyslipidemia in CKD pa-tients after CRRT,which should be monitored before dialysis and take measures to correct.