乳腺癌软脑膜转移的诊断及治疗进展OA

Leptomeningeal metastases(LM)in breast cancer patients are rare,but are usually accompanied by severe symptoms and a very poor prognosis.So far,MRI of the brain and/or spinal cord and cytological examination of cerebrospinal fluid(CSF)are the two primary methods used to diagnose LM.However,the sensitivity of either technique is limited,leading to a long diagnostic process,and delaying treatment.Traditional chemotherapy and targeted therapies used to treat systemic diseases are hampered by the blood-brain barrier.Similarly,the efficacy of intrathecal therapy and radiotherapy is controversial.This review summarized advances in the diagnosis and therapies of LM in breast cancer,in the hopes of providing a reference for clinical practice.