PKM1 is required for embryonic cardiomyocyte proliferation through energetic regulation of NFYa stabilityOA
PKM1 is required for embryonic cardiomyocyte proliferation through energetic regulation of NFYa stability
Dandan Zhang;Dachun Xu;Xiaochen Kou;Yanhong Zhao;Hong Wang;Shaorong Gao;Ke Wei;Lan Kang;Yansong Tang;Wen Ye;Danli Yang;Shengtang Qin;Juntao Liu;Nan Su;Rongrong Huang;Guangzheng Shi
Institute for Regenerative Medicine,Shanghai East Hospital,Shanghai Institute of Stem Cell Research and Clinical Translation,Shanghai Key Laboratory of Signaling and Disease Research,Frontier Science Center for Stem Cell Research,School of Life Sciences and Technology,Tongji University,Shanghai 200092,ChinaDepartment of Cardiology,Clinical Research Unit,Shanghai Tenth People's Hospital,Tongji University School of Medicine,Shanghai 200092,ChinaFrontier Science Center for Stem Cell Research,Tongji University,Shanghai 200092,ChinaFrontier Science Center for Stem Cell Research,Tongji University,Shanghai 200092,ChinaClinical and Translation Research Center of Shanghai First Maternity & Infant Hospital,School of Life Sciences and Technology,Tongji University,Shanghai 200092,ChinaClinical and Translation Research Center of Shanghai First Maternity & Infant Hospital,School of Life Sciences and Technology,Tongji University,Shanghai 200092,China||Frontier Science Center for Stem Cell Research,Tongji University,Shanghai 200092,ChinaInstitute for Regenerative Medicine,Shanghai East Hospital,Shanghai Institute of Stem Cell Research and Clinical Translation,Shanghai Key Laboratory of Signaling and Disease Research,Frontier Science Center for Stem Cell Research,School of Life Sciences and Technology,Tongji University,Shanghai 200092,ChinaInstitute for Regenerative Medicine,Shanghai East Hospital,Shanghai Institute of Stem Cell Research and Clinical Translation,Shanghai Key Laboratory of Signaling and Disease Research,Frontier Science Center for Stem Cell Research,School of Life Sciences and Technology,Tongji University,Shanghai 200092,China||Frontier Science Center for Stem Cell Research,Tongji University,Shanghai 200092,ChinaInstitute for Regenerative Medicine,Shanghai East Hospital,Shanghai Institute of Stem Cell Research and Clinical Translation,Shanghai Key Laboratory of Signaling and Disease Research,Frontier Science Center for Stem Cell Research,School of Life Sciences and Technology,Tongji University,Shanghai 200092,ChinaInstitute for Regenerative Medicine,Shanghai East Hospital,Shanghai Institute of Stem Cell Research and Clinical Translation,Shanghai Key Laboratory of Signaling and Disease Research,Frontier Science Center for Stem Cell Research,School of Life Sciences and Technology,Tongji University,Shanghai 200092,ChinaInstitute of Cancer Stem Cell,Dalian Medical University,Dalian 116044,ChinaInstitute of Cancer Stem Cell,Dalian Medical University,Dalian 116044,ChinaInstitute for Regenerative Medicine,Shanghai East Hospital,Shanghai Institute of Stem Cell Research and Clinical Translation,Shanghai Key Laboratory of Signaling and Disease Research,Frontier Science Center for Stem Cell Research,School of Life Sciences and Technology,Tongji University,Shanghai 200092,ChinaInstitute for Regenerative Medicine,Shanghai East Hospital,Shanghai Institute of Stem Cell Research and Clinical Translation,Shanghai Key Laboratory of Signaling and Disease Research,Frontier Science Center for Stem Cell Research,School of Life Sciences and Technology,Tongji University,Shanghai 200092,ChinaDepartment of Cardiology,Clinical Research Unit,Shanghai Tenth People's Hospital,Tongji University School of Medicine,Shanghai 200092,ChinaDepartment of Cardiology,Clinical Research Unit,Shanghai Tenth People's Hospital,Tongji University School of Medicine,Shanghai 200092,China
PKM1cardiac developmentcardiomyocyte proliferationAMPKNFYa
PKM1cardiac developmentcardiomyocyte proliferationAMPKNFYa
《国家科学评论（英文版）》 2026 (1)
48-63,16
This work was supported by the Key Research and Develop-ment Program,Ministry of Science and Technology of China(2022YFA1103103,2018YFA0800100 and 2017YFA0105600),the National Natural Science Foundation of China(32370870,32070823,32170801 and 92168205),the China Postdoctoral Science Foundation(BX20240261)and the Fundamental Re-search Funds for the Central Universities(22120250336,22120230471 and 22120250374).
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