牙龈卟啉单胞菌在肿瘤发生发展中作用的研究进展OA

Periodontitis is a chronic inflammatory disease.The heterotopic colonization of periodontal pathogens re-sults in the development of several systemic diseases.Porphyromonas gingivalis(P.gingivalis),a key pathogen for peri-odontitis,has been linked to the development of various cancers,such as oral squamous cell carcinoma(OSCC),lung cancer,esophageal cancer,pancreatic cancer,colorectal cancer,cervical cancer,and prostate cancer.P.gingivalis pro-mote the progression of tumor through various mechanisms,P.gingivalis regulates proteins targeting cell cycle and apoptosis to promote proliferation of tumor cells directly,enhances tumor stemness by upregulating the expression of cluster of differentiation 44(CD44)and cluster of differentiation 133(CD133),activates inflammasome and p38/c-Jun N-terminal kinase 1(JNK)pathways,regulates tumor-associated neutrophil(TAN)polarization to remodel the tumor mi-croenvironment,regulates epithelial-mesenchymal transition(EMT)to promote tumor metastasis,remodel macrophage function to evade host immune response,and regulates multi-communicating with symbiotic bacteria.In addition,P.gingivalis accelerates the progression of esophageal cancer,pancreatic cancer,colorectal cancer,and prostate cancer by promoting cell proliferation,inhibiting apoptosis,inducing chronic inflammation,and escaping immunity.However,the oral microbiome is a complex system,whether the interactions between oral bacteria affect tumor progression needs to be further investigated.