多维铁联合右旋糖酐铁口服液治疗儿童缺铁性贫血的临床评价OA
Efficacy of Multi-Dimensional Iron Combined with Iron Dextran Oral Solution in the Treatment of Children with Iron Deficiency Anemia and Its Effects on Serum Ferritin
目的:探讨多维铁联合右旋糖酐铁口服液对儿童缺铁性贫血(IDA)的疗效及对血清铁蛋白(SF)的影响.方法:选取2023年9月至2024年9月沧州市中心医院收治的IDA患儿96例,因个人原因脱落5例,最终入组91例,按随机数表法分为右旋糖酐铁组(右旋糖酐铁口服溶液,45例)与联合组(多维铁口服溶液联合右旋糖酐铁口服溶液,46例).比较两组患儿临床疗效、贫血相关指标、铁代谢相关指标、血清指标及不良反应发生情况等.结果:治疗后,联合组治疗总有效率高于右旋糖酐铁组(P＜0.05).两组患儿红细胞计数(RBC)、血红蛋白(Hb)、平均红细胞血红蛋白浓度(MCHC)、平均红细胞容积(MCV)均升高,且联合组高于右旋糖酐铁组(P＜0.05).两组患儿血清铁(SI)、SF水平均升高,且联合组高于右旋糖酐铁组(P＜0.05).两组患儿总铁结合力(TIBC)均降低,且联合组低于右旋糖酐铁组(P＜0.05).两组患儿血清白细胞介素-6(IL-6)、干扰素-γ(INF-γ)水平均降低,且联合组低于右旋糖酐铁组(P＜0.05).两组患儿血清IL-10水平均升高,且联合组高于右旋糖酐铁组(P＜0.05).结论:多维铁联合右旋糖酐铁口服液治疗IDA患儿能有效补充铁元素,改善贫血症状,安全性较高.
Objective:To probe into the efficacy of multi-dimensional iron combined with iron dextran oral solution in the treatment of children with iron deficiency anemia(IDA)and its effects on serum ferritin(SF).Methods:Ninety-six children with IDA admitted into Cangzhou Central Hospital from Sept.2023 to Sept.2024 were extracted,5 cases dropped out due to personal reasons,and 91 cases were finally enrolled.The children were divided into the iron dextran group(iron dextran oral solution,45 cases)and combined group(multi-dimensional iron oral solution combined with iron dextran oral solution,46 cases)via the random number table method.The clinical efficacy,anemia related indicators,iron metabolism related indicators,serum indicators,and adverse drug reactions of two groups were compared.Results:After treatment,the total effective rate of combined group was higher than that of iron dextran group(P＜0.05).The red blood cell count(RBC),hemoglobin(Hb),mean corpuscular hemoglobin concentration(MCHC),and mean corpuscular volume(MCV)in both groups increased significantly,and the combined group was higher than the dextran iron group(P＜0.05).After treatment,the serum iron(SI)and SF in both groups increased,and the combined group was higher than the dextran iron group(P＜0.05).The total iron binding capacity(TIBC)of both groups decreased,and the combined group was lower than the dextran iron group(P＜0.05).After treatment,the levels of interleukin-6(IL-6)and interferon-γ(INF-γ)in both groups decreased,and the combined group was lower than the dextran iron group(P＜0.05).The level of IL-10 in both groups increased,and the combined group was higher than the dextran iron group(P＜0.05).Conclusion:Multi-dimensional iron combined with iron dextran oral solution in the treatment of children with IDA can effectively supplement the iron elements,improve the anemia symptoms with higher safety.
李琛;刘朝阳;王文娟;齐莹莹
沧州市中心医院,河北沧州 061000沧州市中心医院,河北沧州 061000沧州市中心医院,河北沧州 061000沧州市中心医院,河北沧州 061000
医药卫生
缺铁性贫血多维铁右旋糖酐铁口服液血清铁蛋白
iron deficiency anemiamulti-dimensional ironiron dextran oral solutionserum ferritin
《儿科药学杂志》 2026 (2)
25-28,4
河北省2024年度医学科学研究课题计划项目,编号20241742.
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