锥虫半胱氨酸蛋白酶抑制剂的作用机制及其应用研究进展OA

Trypanosoma is an important parasite that can cause various diseases in humans and animals.Par-ticularly in developing countries,the health problems resulting from trypanosomiasis infection are particu-larly serious.Cysteine proteases play a crucial role in the survival and pathogenicity of Trypanosoma spe-cies,participating in multiple biological processes such as nutrient acquisition,immune evasion and tissue damage.Therefore,the development of inhibitors targeting Trypanosoma cruzi cysteine proteases not only holds significant fundamental research significance,but also has promising application prospects in the clin-ical prevention and control of Chagas disease.This paper reviews the research progress of inhibitors against Trypanosoma cruzi cysteine proteases in recent years,analyzes their mechanism of action and potential ap-plication value in the treatment of Chagas disease,aiming to provide references for related research and promote the development of new therapeutic strategies.