SIRT3在高脂血症和血管内皮功能损伤中的研究进展OA

SIRT3 is an enzyme located in the mitochondria that has stable mitochondrial deacetylation activity.It regulates mitochondrial proteins through deacetylation and plays a crucial role in maintaining redox balance,regulating energy metabolism,and modulating mitochondrial dynamics.SIRT3 can improve vascular endothelial function by regu-lating mitochondrial function,and maintenance of vascular endothelial function is a key link in the prevention and treat-ment of hyperlipidemia.Therefore,it is of great importance to explore the effect of SIRT3 in the prevention and treatment of hyperlipidemia by analyzing its impact on vascular endothelial function.Meanwhile,with reference to the traditional Chinese medicine etiology and pathogenesis of hyperlipidemia and vascular endothelial injury,this article proposes the hypothesis that the change in SIRT3 is associated with viscera/bowels,Qi-blood,and Yin/Yang in traditional Chinese medicine,which may provide new ideas of integrated traditional Chinese and Western medicine for theoretical research into the treatment of hyperlipidemia.