癫痫患者中性粒细胞与淋巴细胞比值的临床价值OA

Objective To investigate the clinical significance of the neutrophil-to-lymphocyte ratio(NLR)in the patients with epilepsy.Methods A total of 199 inpatients with definitely diagnosed epilepsy in the Affiliated Nanjing Tongren Hospital,School of Medicine,Southeast University were enrolled as the study subjects and divided into the generalized convulsive status epilepticus(GCSE,89 cases)and non-status epilep-ticus(NSE,110 cases)based on epilepsy onset situation.The other 155 non-epileptic patients served as the control group.The clinical data and serological indicators were compared among 3 groups.The binary logistic regression was used to analyze the influencing factors of epilepsy onset.The Spearman correlation was used to analyze the correlation between NLR and epilepsy.The receiver operating characteristic(ROC)curve was used to evaluate the predictive value of NLR to epilepsy.Results The WBC,neutrophil(NEU)and NLR lev-els in the GCSE group and NSE group were significantly higher than those in the control group(P<0.05).The binary logistic regression results showed that NLR was the independent influencing factor of epilepsy on-set(P<0.05).The NLR level in different EEG grades had statistical difference between the GCSE group and NSE group.The correlation analysis showed that NLE was positively correlated with GCSE and NSE(P<0.05).The area under the curve(AUC)for NLR in predicting GCSE was 0.847,which in predicting NSE was 0.822.Conclusion NLR has certain correlation with epilepsy.The higher the NLR level,the greater the pos-sibility of evolving into GSCE;NLR is related with the EEG results.NLR combined with EEG for judging GSCE has more clinical significance.