首页|期刊导航|遵义医科大学学报|重视残粒样脂蛋白胆固醇在ASCVD风险管理中的检测与应用

重视残粒样脂蛋白胆固醇在ASCVD风险管理中的检测与应用OA

Importance of the detection and clinical application of remnant lipoprotein cho-lesterol in optimizing ASCVD risk management and therapeutic strategies

中文摘要英文摘要

残粒样脂蛋白胆固醇(RLP-C)是指富含甘油三酯脂蛋白代谢后形成的脂蛋白残粒所含胆固醇的总称,它在动脉粥样硬化性心血管疾病(ASCVD)剩余风险评估中的价值日益受到重视.相较于传统血脂指标,RLP-C能更直接反映致动脉粥样硬化脂蛋白颗粒负荷,尤其适用于他汀治疗后LDL-C达标但仍发生心血管事件者.本文围绕RLP-C的代谢特征与动脉粥样硬化的相关性、RLP-C的检测方法及其在ASCVD风险管理中的应用进行综述,旨在为ASCVD的全面管理与精准防治提供依据与手段.

Remnant lipoprotein cholesterol(RLP-C)refers to the total cholesterol content within the remnant particles derived from the metabolism of triglyceride-rich lipoproteins.Its role in assessing the residual risk of atherosclerotic cardiovascular disease has garnered increasing attention.Compared to traditional lipid parame-ters,RLP-C may more directly reflect the burden of atherogenic lipoprotein particles.This is particularly rele-vant for individuals who experience cardiovascular events despite achieving the recommended low-density lipo-protein cholesterol target with statin therapy.This review focuses on the metabolic characteristics of RLP-C and its association with atherosclerosis,detection methods for RLP-C,and its application in the risk management of ASCVD,aiming to provide a basis and approach for comprehensive management and precise prevention of AS-CVD.

杨雪娇;鄢仁晴;鄢盛恺

遵义医科大学附属医院医学检验科,贵州遵义 563000||遵义医科大学检验医学院,贵州遵义 563006遵义医科大学附属医院医学检验科,贵州遵义 563000||遵义医科大学检验医学院,贵州遵义 563006遵义医科大学附属医院医学检验科,贵州遵义 563000||遵义医科大学检验医学院,贵州遵义 563006

医药卫生

残粒样脂蛋白胆固醇动脉粥样硬化脂质代谢

remnant lipoprotein cholesterolatherosclerosislipid metabolism

《遵义医科大学学报》 2026 (1)

1-6,6

国家自然科学基金资助项目(NO:82070916)遵义市科技计划项目[NO:遵市科合HZ字(2021)185].

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