中药穴位贴敷联合常规西药治疗冠心病心绞痛疗效的Meta分析OA
Meta-Analysis of the Efficacy of Traditional Chinese Medicine Acupoint Application Combined with Conventional Western Medicine in the Treatment of Coronary Heart Disease Angina Pectoris
目的 评估中药穴位贴敷联合常规西药对冠心病心绞痛患者的临床治疗效果.方法 通过计算机检索万方、知网、维普、中国生物医学文献库、PubMed、Embase、Cochrane Library及Web of Science数据库,检索时间设定为建库起至2024年5月,检索内容为穴位贴敷联合常规西药治疗冠心病心绞痛疗效的随机对照试验.应用风险评估工具对纳入的研究进行质量评价,采用RevMan 5.4专业软件进行荟萃分析(Meta分析).结果 纳入21篇文献,共1 800名患者.Meta分析结果显示:与常规西药治疗相比,中药穴位贴敷联合常规西药治疗冠心病心绞痛在提高临床疗效[OR=3.91,95％CI(2.92,5.24),P＜0.000 01]、心电图疗效[OR=1.64,95％CI(1.20,2.23),P=0.002]、硝酸甘油减停率[OR=3.37,95％CI(2.06,5.49),P＜0.000 01]、中医证候疗效[OR=2.38,95％CI(1.29,4.38),P=0.005],减少心绞痛发作频率[SMD=-1.80,95％CI(-2.36,-1.24),P＜0.000 01]、心绞痛发作持续时间[SMD=-1.97,95％CI(-3.07,-0.86),P=0.000 5],降低总胆固醇[SMD=-0.61,95％CI(-1.13,-0.08),P=0.02]、甘油三酯[SMD=-1.30,95％CI(-2.51,-0.10),P=0.03]方面有明显疗效;低密度脂蛋白胆固醇[SMD=-0.52,95％CI(-1.06,0.01),P=0.06]、高密度脂蛋白胆固醇[SMD=0.61,95％CI(-0.05,1.26),P=0.07]的改善差异无统计学意义.结论 中药穴位贴敷联合常规西药治疗冠心病心绞痛较单独使用常规西药效果更佳.
Objective:To evaluate the clinical therapeutic effect of traditional Chinese medicine(TCM)acupoint application combined with conventional western medicine in the treatment of patients with coronary heart disease angina pectoris.Methods:Computerized searches were conducted in WanFang Database,CNKI,VIP Data-base,Chinese Biomedical Literature Database(CBM),PubMed,Embase,Cochrane Library and Web of Science databases.The search period was from the inception of each database to May 2024,focusing on randomized controlled trials(RCTs)of TCM acupoint application combined with conventional western medicine for coronary heart disease angina pectoris.A risk assessment tool was used to evaluate the quality of the included studies,and RevMan 5.4 software was employed for meta-analysis.Results:A total of 21 literatures involving 1 800 patients were included.The meta-analysis results showed that compared with conventional western medicine alone,TCM acupoint application combined with conventional western medicine had significant efficacy in improving clinical efficacy[Oβ=3.91,95％CI(2.92,5.24),P＜0.000 01],electrocardiographic efficacy[OR=1.64,95％CI(1.20,2.23),P=0.002],nitroglycerin reduction and withdrawal rate[OR=3.37,95％CI(2.06,5.49),P＜0.000 01],TCM syndrome efficacy[OR=2.38,95％CI(1.29,4.38),P=0.005],reducing angina pectoris attack frequency[SMD=-1.80,95％CI(-2.36,-1.24),P＜0.000 01],angina pectoris attack duration[SMD=-1.97,95％CI(-3.07,-0.86),P＜0.000 5],decreasing total cholesterol[SSMD=-0.61,95％CI(-1.13,-0.08),P=0.02],triglycerides[SMD=-1.30,95％CI(-2.51,-0.10),P=0.03].However,there were no obvious differences in the low-density lipoprotein choles-terol[SMD=-0.52,95％CI(-1.06,0.01),P=0.06]and the high-density lipoprotein[SMD=0.61,95％CI(-0.05,1.26),P=0.07].Conclusion:TCM acupoint application combined with conventional western medicine is more effective than conventional western medicine alone in the treatment of coronary heart disease angina pectoris.
靳莉莉;刘新灿;兰真真;陈云;陈志豪;成丽;胡婷;张高静;刘岱岳
河南中医药大学第一附属医院,河南郑州 450003||河南中医药大学,河南郑州 450000河南中医药大学第一附属医院,河南郑州 450003||河南中医药大学,河南郑州 450000||中西医防治重大疾病河南省协同创新中心,河南郑州 450000河南中医药大学第一附属医院,河南郑州 450003||河南中医药大学,河南郑州 450000||中西医防治重大疾病河南省协同创新中心,河南郑州 450000河南中医药大学第一附属医院,河南郑州 450003||河南中医药大学,河南郑州 450000||中西医防治重大疾病河南省协同创新中心,河南郑州 450000河南中医药大学第一附属医院,河南郑州 450003||河南中医药大学,河南郑州 450000河南中医药大学第一附属医院,河南郑州 450003||河南中医药大学,河南郑州 450000河南中医药大学第一附属医院,河南郑州 450003||河南中医药大学,河南郑州 450000河南中医药大学第一附属医院,河南郑州 450003||河南中医药大学,河南郑州 450000河南中医药大学第一附属医院,河南郑州 450003||河南中医药大学,河南郑州 450000
医药卫生
冠心病心绞痛中药穴位贴敷随机对照试验系统评价荟萃分析
Coronary heart diseaseAngina pectorisTraditional Chinese medicine acupoint applicationRan-domized controlled trialSystematic reviewMeta-analysis
《中国中医急症》 2026 (1)
1-7,18,8
国家自然科学基金青年科学基金项目(82205020)河南省"科创中原"行动青年人才托举工程(2023HYTP038)河南省中医药科学研究专项(2023ZXZX1156)
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