中草药提取物对羊免疫机能的影响研究进展OA

With the rapid development of animal husbandry,the irrational use of antibiotics in animal production has triggered a series of public health and ecological safety issues,such as drug residues and bacterial resistance,posing serious threats to both human and animal health.Consequently,the development of safe,efficient,and residue-free antibiotic alternatives has become a key research focus in the livestock industry.Chinese herbal medicines,rich in bioactive components such as polysaccharides and polyphenols,are characterized by their wide availability,natural purity,and absence of residues.The active constituents in these herbs can regulate the transcription of related genes through signaling pathways like MAPK,thereby modulating the levels of immune factors and influencing the immune function of organisms.Existing studies indicate that specific extracts from Chinese herbal medicines can significantly elevate serum immunoglobulin IgA,IgG,IgM levels in sheep and modulate the expression of cytokines such as IL-2 and IL-6,thereby enhancing immune function.This review systematically summarizes the molecular mechanisms and signaling pathways through which active components of Chinese herbal medicines regulate immune function in sheep.It aims to provide a theoretical foundation and practical guidance for the scientific application of plant-derived feed additives in animal production systems.