慢性阻塞性肺疾病急性加重期患者继发肺部真菌感染危险因素分析OA

Objective To analyze risk factors for secondary pulmonary fungal infection in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 129 patients with AECOPD who were treated at the 989th Hospital of the Joint Logistics Support Force.Chinese PLA from January 2022 to January 2025 were enrolled.Clinical data of patients with and without pulmonary fungal infection were analyzed to identify risk factors for secondary pulmonary fungal infection.Results Among the 129 patients with AECOPD.45 developed pulmonary fungal infection(34.88%).From these 45 patients.a total of 67 fungal strains were recovered.including Candida albicans(27 isolates.40.30%).Aspergillus fumigatus(15 isolates.22.38%).and Aspergillus flavus(11 isolates.16.42%).The proportions of patients aged＞60 years.those with hypoproteinemia.those with a history of mechanical ventilation.and those with antibiotic use for＞10 days were significantly higher in the infected group than in the non-infected group(P＜0.05).Multivariate analysis showed that age＞60 years.hypoproteinemia.a history of mechanical ventilation.and antibiotic use for＞10 days were risk factors for pulmonary fungal infection(P＜0.05).Conclusion Age＞60 years.hypoproteinemia.a history of mechanical ventilation.and duration of antibiotic use＞10 days are closely associated with secondary pulmonary fungal infection in patients with AECOPD.