沙门菌耐药基因水平转移机制及影响因素OA

Salmonella is a common foodborne pathogen worldwide.With the promotion and use of antibiotics,more and more Salmonella produce or acquire antibiotic resistance genes(ARG)through vertical transmission and horizontal gene transfer(HGT),causing widespread dissemination of antibiotic resistance.In the process of horizontal gene transfer,ARGs are mainly carried by mobile genetic elements(MGEs),which are important mediators of HGT and can facilitate the spread of ARGs.Among them,MGEs mainly include plasmids,integrons and conjugative elements,transposons,insertion sequences,and phages,etc.MGE-associated transfer mechanisms,accessory gene compositions,and relationships between ARG dissemination and animal sources and geographic environments vary.The aim of this review is to outline the HGT mechanism of ARG in Salmonella,the different MGE-mediated HGT mechanisms and the influencing factors of HGT occurrence and development,which is of great significance for the in-depth investigation of the HGT mechanism of drug resistance in Salmonella.