色氨酸代谢产物调控肠道氧化应激研究进展OA

The gastrointestinal tract is not only a place where nutrients digest,absorb and metabolize,but also serves as both a primary source and a major target of reactive oxygen species(ROS).Intestinal health is a cornerstone of animal growth and a critical determinant of livestock production efficiency.Tryptophan,an essential amino acid,is metabolized by both host cells and gut microbiota into various bioactive compounds,such as indole,kynurenine and 5-hydroxytryptamine.These metabolites act as endogenous ligands to regulate intestinal oxidative stress and inflammatory damage.This review summarizes the host and microbial pathways of intestinal tryptophan metabolism,explores the physiological functions of tryptophan metabolites in modulating oxidative stress and tissue repair,and discusses the role of microbial tryptophan metabolism in potential nutritional interventions,including probiotics and nutritional supplements.These findings aim to inform research on nutritional strategies for managing gut health.