妊娠期高血压疾病患者胎盘微循环参数与不良妊娠结局的关系OA

Objective:To investigate the relationship between blood flow pulse index(PI),resistance index(RI),ratio of maximum systolic velocity to end-diastolic velocity(S/D)and time average velocity(TAV)of placental microcirculation parameters and adverse pregnan-cy outcomes in patients with hypertensive disorders in pregnancy(HDP).Methods:In this study,142 hospitalized pregnant women with hypertension at the beginning of pregnancy admit-ted to our hospital from January 2022 to January 2025 were selected to be included in the study group,and 62 normal healthy pregnant women at the same gestational week were selected as ref-erences to be included in the health group.The placental microcirculation parameters PI,RI,S/D and TAV were measured by ultrasound in two groups.Differences in placental microcircula-tion parameters PI,RI,S/D,TAV and incidence of adverse pregnancy outcomes between the healthy and research groups were compared.Differences in placental microcirculation parame-ters PI,RI,S/D and TAV between the good pregnancy group and the bad pregnancy group were compared.The predictive value of placental microcirculation parameters PI,RI,S/D and TAV for adverse pregnancy outcomes were analyzed by ROC.The correlation between PI,RI,S/D and TAV and pregnancy outcome was analyzed by Spearman.Results:Compared with the healthy group,the incidence of PI,RI,S/D and adverse pregnancy outcomes in the study group was significantly higher,and the incidence of TAV was significantly lower(all P<0.05).Com-pared with the good pregnancy group,the incidence of PI,RI,S/D and adverse pregnancy out-comes in the bad pregnancy group was significantly higher,and the incidence of TAV was sig-nificantly lower(all P<0.05).ROC results showed that the AUC of PI,RI,S/D and TAV in the diagnosis of adverse pregnancy outcomes was 0.931,which was significantly higher than that of single detection(P<0.05).Spearman correlation analysis showed that PI,RI,S/D were sig-nificantly positively correlated with adverse pregnancy outcomes,and TAV was significantly neg-atively correlated with adverse pregnancy outcomes(r=0.669,0.687,0.631,0.735,all P<0.001).Conclusion:The placental microcirculation parameters PI,RI and S/D were signifi-cantly higher in pregnant women than those in normal women,and the TAV was significantly lower.The combined detection of placental microcirculation parameters has high predictive val-ue for adverse pregnancy outcomes.