子宫颈上皮内瘤变2级(CIN2)管理中国专家共识(2026版)OA

Persistent infection with high-risk human papillomavirus(HR-HPV)is the primary etiologi-cal factor for cervical intraepithelial neoplasia grade 2(CIN2).The accuracy of CIN2 diagnosis is affected by the limitations of colposcopic biopsy and the variability in pathological interpretation.Underdiagnosis or overdiagno-sis may lead to missed detection of more severe lesions or overtreatment.Particularly for young women and those with fertility requirement,overtreatment can increase the risk of adverse pregnancy outcomes in the future.Based on evidence-based medicine and China's national conditions,this consensus proposes refined management strate-gies for the CIN2 women.Comprehensive consideration of multiple factors(including age,fertility needs,and le-sion characteristics,etc)is required,for low-risk individuals eligible for conservative observation,close monito-ring and dynamic assessment should be implemented.For high-risk individuals ineligible for conservative obser-vation,it is recommended to undergo excisional treatment to reduce the risk of missed diagnosis and disease pro-gression.For special populations of CIN2:follow-up is the mainstay for pregnant women,with reassessment post-delivery;excisional treatment is preferred for postmenopausal women;and immunocompromised women require individualized assessment,enhanced monitoring,or active treatment.