强直性脊柱炎患者免疫功能、凝血功能指标与脊柱活动度的相关性OA
Correlation between immune function,coagulation function indicators and spinal mobility in patients with ankylosing spondylitis
目的 探讨强直性脊柱炎(AS)患者免疫功能、凝血功能指标与脊柱活动度的相关性.方法 选取 2019-11 至2024-11于武警特色医学中心就诊的AS患者150例,根据AS疾病活动指数(BASDAI)分为活动期组和稳定期组,比较两组凝血与纤溶活性相关指标、血小板计数(PLT)、红细胞沉降率(ESR)、C反应蛋白(CRP)、血栓形成相关因子、Th17/Treg及相关因子、氧化应激指标水平,分析BASDAI、巴氏功能指数(BASFI)与上述指标的相关性.结果 与稳定期组比较,活动期组的纤维蛋白原(FIB)、D-二聚体、PLT、纤维蛋白降解产物(FDP)、血栓素A2(TXA2)、纤溶酶原激活剂抑制剂(PAI)、ESR、CRP、Th17、Th17/Treg、白介素(IL)-17、IL-23、丙二醛水平更高,而活化部分凝血活酶时间(APTT)、前列环素(PGI2)、Treg、IL-10、转化生长因子-β(TGF-β)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)水平更低(P<0.05);相关性分析结果显示,AS患者BASDAI、BASFI指数与D-二聚体、PLT、FDP、TXA2、PAI、ESR、CRP、Th17、Th17/Treg、IL-17、IL-23、MDA水平呈正相关,而与APTT、PGI2、Treg、IL-10、TGF-β、SOD、CAT呈负相关(P<0.05).结论 AS患者凝血功能、免疫功能和氧化应激指标与病情活动和脊柱活动度存在密切联系.
Objective To explore the correlation between immune function,coagulation function indicators and spinal mobility in patients with ankylosing spondylitis(AS).Methods A total of 150 AS patients who visited Characteristics Medical Center of Chi-nese People's Armed Police Force from November 2019 to November 2024 were selected and divided into an active stage group and a stable stage group according to Bath Ankylosing Spondylitis Disease Activity Index(BASDAI).The levels of indicators related with co-agulation and fibrinolytic activity,platelet count(PLT),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),factors re-lated with thrombosis,Th17/Treg and related factors,and oxidative stress indicators were compared between the two groups.The cor-relations between BASDAI,Bath Ankylosing spondylitis Functional Index(BASFI)and the above indicators was analyzed.Results Compared with the stable stage group,the levels of fibrinogen(FIB),D-dimer,PLT,fibrin degradation products(FDP),thrombin A2(TXA2),plasminogen activator inhibitor(PAI),ESR,CRP,Th17,Th17/Treg,interleukin(IL)-17,IL-23 and ma-londialdehyde(MDA)were higher in the active stage group,while the levels of activated partial thromboplastin time(APTT),prosta-cyclin(PGI2),Treg,IL-10,transforming growth factor-β(TGF-β),superoxide dismutase(SOD),and catalase(CAT)were lower(P<0.05);Correlation analysis showed that BASDAI and BASFI in AS patients were positively correlated with D-dimer,PLT,FDP,TXA2,PAI,ESR,CRP,Th17,Th17/Treg,IL-17,IL-23,and MDA,and negatively correlated with APTT,PGI2,Treg,IL-10,TGF-β,SOD and CAT(P<0.05).Conclusions The coagulation function,immune function and oxidative stress indicators in AS pa-tients are closely related with the disease activity and spinal mobility.
孙亮;孙占飞;徐变霞;刘秀稳;陈伟建
300162 天津,武警特色医学中心呼吸与重症医学科300162 天津,武警特色医学中心呼吸与重症医学科300162 天津,武警特色医学中心军人体检鉴定科300162 天津,武警特色医学中心呼吸与重症医学科300162 天津,武警特色医学中心呼吸与重症医学科
医药卫生
强直性脊柱炎凝血功能免疫脊柱活动度相关性
ankylosing spondylitiscoagulation functionim-munityspinal mobilitycorrelation
《武警医学》 2026 (1)
1-4,9,5
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