肠溶植物滴丸囊皮配方优化OA

The aim of this study is to optimize the preparation process of enteric plant dropping pills and to enhance their comprehensive properties in order to promote their application in food and biomedical fields.Single factor experiments and response surface methodology were employed to optimize the optimal formula:pullulan 2.875％,sodium alginate 0.702％,mκ-carrageenan∶mgellan gum=3∶1,glycerol 2.5％,KCl 0.20％.The results of the verification experiments showed that the tensile strength of the resulting film was 10.98±0.42 MPa and the elongation at break was 55.31％±0.65％,which were similar to the theoretical predictions and showed good mechanical properties.Moreover,the enteric plant dropping pills made from this formula were tested in simulated gastric fluid and simulated intestinal fluid for 2 h and 3 h,respectively,and showed no signs of disintegration or softening.Whereas the dropping pills completely disintegrated in simulated colonic fluid within 11±3 min,meeting the requirements of the Pharmacopoeia of the People's Republic of China(2020 edition).Meanwhile,the dissolution rates of the dropping pills in gastric and intestinal fluids were 38.32％±4.63％and 294.92％±7.33％,respectively,and there was no erosion or deformation,showing good dissolution properties.This study provides a theoretical basis and technical support for the preparation of enteric plant dropping pills with excellent mechanical properties,and strongly promotes their application expansion in the fields of food and medicine.