膳食甜味剂影响运动对肥胖及多器官代谢紊乱的改善研究进展OA

Exercise ameliorates obesity-induced fat accumulation,insulin resistance and inflammatory response through AMPK/SIRT1/PPARs signaling pathways,yet its efficacy may be modulated by dietary factors.Notably,the excessive consumption of sugar adversely affects host health.The substitution of high-calorie sucrose with low-calorie functional sweeteners has gained widespread popularity among sports enthusiasts and people seeking for weight reduction.Nevertheless,the intricate relationship between sweeteners and host energy metabolism,fat metabolism,and immune health remains largely unexplored.Given the pivotal roles played by exercise and functional sweetener intake in the physiology of obesity and its related complications,we systematically reviewed the impacts of exercise on mitigating obesity-induced dysfunctions across multiple organs(e.g.,cardiovascular,cerebral vascular,hepatic,renal,intestinal,skeletal muscle,and adipose tissues).Moreover,impacts of distinct sweeteners on core regulating targets(e.g.,AMPK/SIRT1/PPARs,STAT3/NF-κB/Smad,PI3K/Akt signaling pathways)of exercise for combating obesity and its related metabolic diseases were then summarized to illustrate potential synergistic or antagonistic effects of sweeteners on the health effects of exercise.This review furnishes theoretical basis and practical guidance aiming for optimization of exercise strategies that could successfully prevent obesity and improve weight maintenance.