多酚刻蚀ZIF-8对金黄色葡萄球菌的灭菌效果OA

The limited visible light absorption and relatively large bandgap of zeolitic imidazolate framework-8(ZIF-8)substantially restrict its antibacterial efficacy under visible light irradiation.Herein,a novel visible-light-responsive antibacterial nanocomposite,EGCG@ZIF-8,was synthesized via post-synthetic modification through the etching of ZIF-8 with epigallocatechin gallate(EGCG).Under visible light irradiation,EGCG@ZIF-8 can efficiently generate reactive oxygen species(ROS),demonstrating a antibacterial rate of 99.999 9％against Staphylococcus aureus within 60 min,which significantly surpassed the performance of pristine ZIF-8.Furthermore,EGCG@ZIF-8 retained robust antibacterial activity even after five consecutive usage cycles.The incorporation of EGCG narrowed the bandgap of ZIF-8,promoting the separation and migration of photogenerated electron-hole pairs,which enhanced the visible-light photocatalytic performance of the composite and subsequently boosted ROS generation.In addition,in vitro cytotoxicity assays confirmed the outstanding biocompatibility of EGCG@ZIF-8.This study not only offers a straightforward and efficient approach for synthesizing high-performance antibacterial composites,but also paves the way for the development of innovative visible-light-driven antibacterial materials,underscoring its substantial scientific and practical significance.