花椒精油微胶囊咀嚼片配方及降脂性能研究OA

To explore the preparation process and in vitro hypolipidemic activity of Zanthoxylum bungeanum essential oil microcapsule chewable tablets,thereby enhancing their application value,this study investigates the addition amounts of raw materials,skimmed milk powder,sweeteners and fillers via single-factor experiments and orthogonal tests,and determines the tablets'hardness,weight variation,thickness,moisture content,in vitro hypolipidemic capacity and hygiene indicators.The optimal formulation for the chewable tablets is as follows:6%raw material addition,40%skimmed milk powder,18%sweetener,35%filler,0.5%citric acid,and 0.5%magnesium stearate.Under this formulation,the tablets achieve a 55.4%adsorption rate for sodium taurocholate,50.5%for sodium glycocholate.The cholesterol adsorption rate is 39%at pH 2.0 and 48.3%at pH 7.0.The total number of colonies in the chewable tablets is measured at<10 CFU/g,coliform count at<10 CFU/g,and no lead is detected.All indicators comply with the national standards.The Zanthoxylum bungeanum essential oil microcapsule chewable tablets exhibit a pleasant taste,satisfactory chewability and definite lipid-lowering capacity.