大分子防晒剂对防晒产品温和度的影响OA

This study evaluates the impact of macromolecular sunscreen agents on the mildness of sunscreen products.Using assays including chorioallantoic membrane vascular tests,patch tests,and skin phototoxicity assessments,we compared three types of formulations:conventional sunscreens primarily containing small-molecule UV filters,sunscreens primarily containing macromolecular UV filters,and macromolecular sunscreen formulations combined with soothing active ingredients.Results show that,compared to conventional small-molecule systems,macromolecular sunscreen-based formulations reduce skin irritation and exhibit milder ocular irritation in HET-CAM tests.The addition of natural soothing actives further mitigates skin discomfort and inflammatory responses potentially triggered by UV exposure or formulation components,synergistically enhancing overall product mildness and safety.