METRNL基因多态性与2型糖尿病的相关性OA

Objective:To investigate the association between the polymorphisms of meteorin-like protein(METRNL)gene rs4986080 and type 2 diabetes mellitus(T2DM).Methods:A total of 467 subjects were selected,including 315 T2DM patients and 152 individuals with normal glucose tolerance(NGT).The polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)method was used to detect the polymorphisms of METRNL gene rs4986080 in all subjects,then analyzed the association between these polymorphisms and T2DM.Results:The constituent ratio of GG genotype and the frequency of G allele at rs4986080 locus of METRNL gene was higher in the T2DM group compared to the NGT group(P＜0.05).Compared to individuals with GG genotype at the METRNL gene rs4986080 locus,those with AA+AG genotypes showed significant lower waist-to-hip ratio,fasting plasma glucose(FPG),2-hour postprandial glucose(2hPG),glycated hemoglobin(HbA1c),and homeostasis model assessment of insulin resistance(HOMA-IR)(P＜0.05).Logistic regression analysis showed that A allele at rs4986080 locus of METRNL gene was probably a protective factor for T2DM.Conclusion:The polymorphisms of METRNL gene rs4986080 may be associated with the occurrence of T2DM,and A allele may be a protective factor for T2DM.