基于18F-FDG PET/CT的棕色脂肪组织特征参数与冠状动脉钙化的相关性分析OA
Correlation between 18F-FDG PET/CT-derived brown adipose tissue characteristics and coronary artery calcification
目的:探讨棕色脂肪组织(brown adipose tissue,BAT)在18 F-FDG PET/CT图像中的特征参数与冠状动脉钙化的相关性.方法:收集2013年12月至2024年4月期间于江苏大学附属医院行18F-FDG PET/CT检查的2 399例患者,经1∶1倾向性评分匹配(propensity score matching,PSM)并根据BAT是否阳性分为BAT阳性组(n=171)和BAT阴性组(n=171)例,分析两组间一般临床资料和冠状动脉钙化发生率的差异.分析BAT阳性组患者颈部、锁骨上窝、腋窝、纵隔、脊柱旁及腹部6个解剖部位BAT图像特征参数的差异,筛选出BAT活性最高的部位(脊柱旁),进一步分析不同冠状动脉钙化累及分支数、不同冠状动脉钙化严重程度组间脊柱旁BAT图像特征参数的差异.结果:PSM后BAT阳性组冠状动脉钙化发生率和冠状动脉钙化积分显著低于阴性组.BAT阳性组6个解剖部位中脊柱旁BAT的SUVmax最高,与腹部和腋窝BAT的SUVmax差异均有统计学意义(均P＜0.001);脊柱旁BAT的SUVmean与腋窝BAT的SUVmean差异有统计学意义(P＜0.001),但与其他解剖部位的SUVmean差异无统计学意义(均P＞0.05);脊柱旁BAT体积和表面积与腹部及腋窝BAT差异均有统计学意义(均P＜0.001).随着冠状动脉钙化累及分支数和严重程度增加,脊柱旁BAT各特征参数呈降低趋势(均P＜0.01).结论:BAT的存在与较低的冠状动脉钙化风险相关,脊柱旁BAT可能对冠状动脉钙化的发生发展存在潜在的抑制效应.
Objective:To investigate the correlation between the characteristic parameters of brown adipose tissue(BAT)and coronary artery calcification in 18F-FDG PET/CT images.Methods:A total of 2 399 patients who underwent 18F-FDG PET/CT examination at the Affiliated Hospital of Jiangsu University from December 2013 to April 2024 were collected.After 1∶1 propensity score matching(PSM),the patients were divided into BAT positive group(n=171)and BAT negative group(n=171)according to whether BAT was positive.Differences in general clinical data and the incidence of coronary artery calcification between the two groups were analyzed.Differences in BAT imaging characteristic parameters among six anatomical sites(the neck,supraclavicular fossa,axilla,mediastinum,paravertebral region,and abdomen)in patients of the BAT-positive group were analyzed,and the site with the highest BAT activity(the paravertebral region)was screened out.Furthermore,differences in paravertebral BAT imaging characteristic parameters among groups with different numbers of coronary artery calcification-involved branches and different severities of coronary artery calcification were analyzed.Results:After PSM,the incidence of coronary artery calcification and the coronary artery calcium score in the BAT positive group were significantly lower than those in the BAT negative group.In the BAT positive group,the SUVmax of paravertebral BAT was the highest among the six anatomical sites,and the difference was statistically significant compared with the SUVmax of abdominal and axillary BAT(all P＜0.001).The SUVmean of paravertebral BAT significantly differed from that of axillary BAT(P＜0.001),but showed no significant differences with other anatomical sites(all P＞0.05).Both the volume and surface area of paravertebral BAT demonstrated statistically significant differences compared to abdominal and axillary BAT(all P＜0.001).As both the number of coronary artery branches involved and the severity of calcification increased,all characteristic parameters of paravertebral BAT progressively decreased(all P＜0.01).Conclusion:The presence of BAT is associated with a lower risk of coronary artery calcification.Paravertebral BAT may have a potential inhibitory effect on the occurrence and development of coronary artery calcification.
杨浩;朱海涛;易义德;宋廉;张龙江;曹雄锋
江苏大学附属医院影像科,江苏镇江 212001江苏大学附属医院影像科,江苏镇江 212001江苏大学附属医院影像科,江苏镇江 212001江苏大学附属医院影像科,江苏镇江 212001江苏大学附属医院影像科,江苏镇江 212001江苏大学附属医院影像科,江苏镇江 212001
医药卫生
棕色脂肪组织18F-FDG PET/CT冠状动脉钙化倾向性评分匹配
brown adipose tissue18F-FDG PET/CTcoronary artery calcificationpropensity score matching
《江苏大学学报（医学版）》 2026 (1)
24-29,6
镇江市重点研发计划社会发展项目(SH2023017)江苏大学医教协同创新基金项目(JDY2023003)江苏省社会发展面上项目(BE2023759)
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