基于铁死亡、炎症和氧化应激探讨参芪地黄汤治疗糖尿病肾病研究进展OA

Ginseng and Astragalus and Rehmannia Decoction,as a representative formula for treating diabetic kidney disease(DKD),may exert its therapeutic effects through potential mechanisms including:regulating the expression of genes related to iron and lipid me-tabolism via its antioxidant effects;inhibiting key regulators of ferroptosis such as hypoxia-inducible factor-1α and tumor suppressor pro-tein p53,etc.;and enhancing antioxidant enzyme activity to block lipid peroxidation,thereby mitigating ferroptosis-mediated cellular damage.However,research in this field is still in its infancy and currently faces the following challenges:(1)The mechanism research requires further depth.Although preliminary research has elucidated some of the pharmacodynamic mechanisms of Ginseng and Astraga-lus and Rehmannia Decoction,more in-depth molecular biology experiments are needed to systematically explain its precise regulation of ferroptosis-related genes and signaling pathways,as well as the synergistic effects of its multiple components.(2)Combined therapy strategies urgently need exploring.Given the complexity of DKD pathogenesis,single therapeutic approaches often have limitations.Fu-ture studies should focus on exploring combined application strategies for Ginseng and Astragalus and Rehmannia Decoctio with Western medicine,other Chinese medicinal compounds,or TCM external therapies to achieve synergistic effects through multiple pathways,there-by providing patients with more optimized treatment options.(3)Clinical evidence-based is lacking.Current research is predominantly limited to animal experiments,and there is a lack of high-quality clinical research data.In the future,it is necessary to conduct large-scale clinical trials to confirm the human efficacy of this decoction in treating DKD by inhibiting ferroptosis.A thorough elucidation of the specific mechanisms by which Ginseng and Astragalus and Rehmannia Decoction regulates ferroptosis will aid in exploring its poten-tial for treating various diseases and provide new insights and targets for clinical translation.