基于PI3K/AKT通路探讨中医药治疗糖脂代谢性疾病OA

Metabolic diseases are chronic conditions resulting from the combined effects of genetic,environmental,and other factors,and have become a major global health threat.The PI3K/AKT signaling pathway is one of the core pathways regulating body metabolism and plays a crucial regulatory role in the occurrence and development of various metabolic diseases.The onset and progression of this kind of diseases are often accompanied by imbalances or disorders in the metabolism of various substances within the body,such as sugars,lip-ids,and proteins.TCM can influence processes like cell proliferation,differentiation,apoptosis,and autophagy,etc.by modulating the PI3K/AKT signaling pathway,thereby improving metabolic disturbances of glucose,lipids,proteins,etc.,and demonstrating significant potential in the prevention and treatment of metabolic diseases.However,the pathogenesis of metabolic diseases involves multiple signa-ling pathways and molecular targets,which collectively affect disease progression through complex regulatory networks.Most current re-search remains still focuses on the effects of single formula or medicine on a specific pathway or a limited number of targets within a sin-gle cell type,lacking systematic and in-depth exploration of the holistic mechanisms.Therefore,it is necessary to further elucidate the interactions between the PI3K/AKT signaling pathway and other cells,molecules,and pathways in the future,and clarify the holistic reg-ulatory mechanisms of TCM at the multi-target and multi-pathway levels,which will provide new strategies for the prevention and treat-ment of metabolic diseases and offer new insights for the development and optimization of related medicines.