血清PCSK9 LTB4 ADAM17与慢性萎缩性胃炎患者病情进展的相关性分析OA

Objective:To investigate the correlation between the levels of serum proprotein convertase subtilase 9(PCSK9),leukotriene B4(LTB4),and a disintegrin and metalloproteinase 17(ADAM 17)in pa-tients with chronic atrophic gastritis(CAG)and disease progression,and analyze their predictive value for disease progression.Methods:A prospective study was conducted on 210 patients with CAG from January 2021 to January 2023.Patients were divided into a progression group and a non-progression group based on whether they experienced disease progression within 2 years after treatment.The clinical data,serum levels of PCSK9,LTB4,and ADAM17 were compared between the two groups.Logistic regression analysis and restricted cubic spline(RCS)curve analysis were used to analyze the relationship between serum PCSK9,LTB4,and AD-AM17 and disease progression,and stratified analysis was conducted.The predictive value of serum PCSK9,LTB4,and ADAM17 for disease progression was evaluated using the receiver operating characteristic(ROC)curve.Results:The proportion of Hp infection,alcohol consumption history,and spicy diet in the progression group were higher than those in the non-progression group,while the PGⅠ/PGⅡ ratio was lower than that in the non-progression group(P<0.05);the levels of serum PCSK9,LTB4,and ADAM17 in the progression group were(188.73±30.17)ng/mL,(9.52±2.06)pg/mL,and(74.56±12.25)ng/L,respectively,which were significantly higher than those in the non-progression group(160.49±25.64)ng/mL,(7.78±1.51)pg/mL,and(63.17±9.44)ng/L(P<0.05);after excluding other factors such as Hp infection,alcohol consumption history,spicy diet,and PGⅠ/PGⅡ ratio,serum PCSK9,LTB4,and ADAM17 remained inde-pendent factors for the progression of CAG(P<0.05);when serum PCSK9 was≥144.69 ng/mL,LTB4 was≥7.01 pg/mL,and ADAM17 was≥67.16 ng/L,there was a significant correlation with the progression of CAG(P<0.05);there was an interactive effect between serum PCSK9,LTB4,ADAM17,Hp infection,and PGⅠ/PGⅡ ratio in the progression of CAG(interaction P<0.05);the AUCs of serum PCSK9,LTB4,AD-AM17,and their combination for predicting the progression of CAG were 0.763,0.755,0.780,and 0.918,respectively,and the AUC of the combination was significantly higher than that of the single index(P<0.05).Conclusion:The levels of serum PCSK9,LTB4,and ADAM17 increase in patients with CAG progres-sion,and are significantly correlated with CAG progression.Combined detection of their levels has certain pre-dictive value for CAG progression.