深度学习辅助中医望诊的抑郁症诊断模型研究OA
Deep learning-assisted diagnosis model of depression based on TCM facial inspection
目的 利用深度学习技术构建抑郁症面部诊断模型,为早期中医望诊识别抑郁症提供新方法.方法 纳入437 例研究对象(抑郁症肝郁脾虚证 210 例、肝郁脾虚证非抑郁症 114 例、健康对照113 名),按标准化流程采集面部图像.剔除模糊、遮挡及姿态异常图像后,通过旋转、缩放、镜像、平移及添加高斯噪声对图像进行扩增,并按 8:1:1划分为训练集、验证集和测试集.采用Effi-cientNet、MobileNet V3 及ResNet18 构建分类模型,通过准确率、参数量、收敛速度及混淆矩阵评估模型性能,并利用类激活映射(class activation mapping,CAM)分析模型决策时对面部特征的关注区域.结果 ①EfficientNet准确率最高(98.6%),参数量适中(4.01 M),收敛速度较快,MobileNet V3 次之(准确率92.7%,参数量1.52M),ResNet18 准确率最低(92.2%)且参数量最大(11.18 M);②混淆矩阵中,EfficientNet对三类人群的误判率最低;③CAM可视化显示,EfficientNet决策时除关注眼周区域外,还对嘴周区域进行识别.结论 基于深度学习构建的中医面部图像抑郁症识别模型具有良好的预测性能,为中医智能望诊辅助识别抑郁症提供了客观证据.
Objective To develop a deep learning-based facial diagnostic model for depression,providing a novel approach for early recognition of depression through Traditional Chinese Medicine(TCM)facial inspection.Methods A total of 437 participants were enrolled,including 210 patients with depression of the liver-qi stagnation and spleen-deficiency pattern,114 non-depressed individuals with the same TCM pattern,and 113 healthy controls.Facial images were collected following standardized procedures.After excluding blurred,occluded,or abnormally posed images,data augmentation was performed using rotation,scaling,flipping,translation,and Gaussian noise.The dataset was divided into training,validation,and test sets in an 8:1:1 ratio.Classification models were constructed using EfficientNet,MobileNet V3,and ResNet18.Model performance was evaluated in terms of accuracy,parameter size,convergence speed,and confusion matrix.Class activation mapping(CAM)was employed to visualize the regions of facial attention contributing to model decisions.Results(1)EfficientNet achieved the highest accuracy(98.6%),with a moderate parameter size(4.01 M)and fast convergence,followed by MobileNet V3(accuracy 92.7%,1.52 M parameters),while ResNet18 showed the lowest accuracy(92.2%)and the largest parameter size(11.18 M).(2)The confusion matrix revealed that EfficientNet exhibited the lowest misclassification rate among the three groups.(3)CAM visualization demonstrated that EfficientNet not only focused on the periocular region but also on the perioral area when making predictions.Conclusion Deep learning-based facial image analysis can effectively extract depression-related facial expression features,providing objective evidence to support intelligent TCM facial diagnosis and assist in the recognition of depressive disorders.
李红培;韩振蕴;胡文悦;王浛宇;李彦良
北京中医药大学深圳医院(龙岗) 深圳 518172北京中医药大学东方医院北京中医药大学深圳医院(龙岗) 深圳 518172北京中医药大学深圳医院(龙岗) 深圳 518172北京中医药大学深圳医院(龙岗) 深圳 518172
医药卫生
抑郁症望诊面部图像深度学习人工智能诊断
depressionTCM inspection diagnosisfacial imagesdeep learningartificial intelligence diagnosis
《现代中医临床》 2026 (1)
27-32,6
国家重点研发计划(No.2019YFC1710103)深圳市"医疗卫生三名工程"项目资助(No.SZZYSM202105010)深圳市龙岗区科技创新专项资金医疗卫生技术攻关项目(No.LGKCYLWS2022012)深圳市龙岗区医学重点学科建设项目
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