中西医结合防治胃"炎癌转化"的研究及创新探索OA
Research and innovative exploration of integrated traditional Chinese and Western medicine in preventing and treating gastric"inflammatory cancer transformation"
肠型胃癌的发生经历了非萎缩性胃炎-萎缩性胃炎-肠上皮化生-上皮内瘤变-胃癌的"炎癌转化"过程,如何发挥中西医结合或者协同攻关的优势以阻断"炎癌转化",始终是本领域的研究热点及难点.随着"炎癌转化"机制被不断深入揭示,西医学筛查与早诊早治技术的革新、风险分层诊疗体系的建立,以及中医药的有效干预,我国胃癌的发病率有所下降.如何进一步发挥中医学治未病思想中"既病防变"的理论和实践优势,使防治关口进一步前移,发现更有效和可靠的阻断胃"炎癌转化"这一动态演变过程的策略和创新药物,是要解决的问题和目标.本文评述了本领域基础研究、临床研究的最新进展,分析了中医药高水平临床研究及中西医结合诊疗路径构建和疗效评价标准、中药复杂体系整合机制揭示等方面存在的问题,探讨了多学科交叉背景下的攻关方向及解决策略,以期为更有效阻断"炎癌转化"、构建具有中国特色的胃癌防控体系,以及进一步提升胃癌的防控水平提供思路与借鉴.
The development of intestinal-type gastric cancer follows a progression from non-atrophic gastritis—atrophic gastritis—intestinal metaplasia—epithelial dysplasia—gastric cancer,known as the"inflammation-cancer transformation."Leveraging the advantages of integrated traditional Chinese and Western medicine,while collaborating to inhibit this transformation,remains a research focus and challenge.The incidence of gastric cancer in China has declined with the continuous elucidation of the mechanisms behind inflammation-cancer transformation,innovations in early screening and diagnosis techniques in Western medicine,the establishment of risk stratification and treatment systems,and effective interventions through traditional Chinese medicine.Leveraging the theoretical and practical advantages of the"preventing disease before it occurs"philosophy of traditional Chinese medicine,particularly the concept of"preventing transformation in existing diseases,"is essential.This approach emphasizes shifting the focus of prevention and treatment to earlier stages of disease progression.Developing more effective and reliable strategies and innovative drugs that block the dynamic progression of the"inflammation-cancer transformation"in gastric cancer remains a key goal.This article reviews the latest progress in both basic and clinical research in this field,the issues related to high-level clinical research in traditional Chinese medicine,the construction of integrated diagnosis and treatment pathways combining Chinese and Western medicine,the establishment of efficacy evaluation standards,and the elucidation of the integration mechanisms of the complex system of traditional Chinese medicine.It also explores research directions and solutions within the context of multidisciplinary collaboration to provide insights and references to block inflammation-cancer transformation and to construct a gastric cancer prevention and control system with Chinese characteristics,thereby further enhancing the level of gastric cancer prevention and control.
丁霞;王琦;李兆申
北京中医药大学 北京 100029北京中医药大学 北京 100029国家消化系统疾病临床医学研究中心
医药卫生
中西医结合炎癌转化胃癌多学科交叉
integrated traditional Chinese and Western medicineinflammation-cancer transformationgastric cancermultidisciplinary integration
《北京中医药大学学报》 2026 (1)
1-9,9
国家四大慢病重大专项(No.2025ZD0545100,No.2025ZD0545101)国家自然科学基金面上项目(No.82374292)国家中医药管理局中医药创新团队及人才支持计划项目(No.ZYYCXTD-C-202401)安徽省科技重大专项中医药科技攻关项目(No.202303a0702003) Non-communicate Chronic Diseases National Science and Technology Major Projects of China(Nos.2025ZD0545100 and 2025ZD0545101)
评论