基于功能性近红外光谱研究声磁配对刺激对运动输出及脑功能连接的影响OA

Objective:To verify the long-term potential effect of acoustic-magnetic paired associative stimulation(AM-PAS)on peripheral motor output and,using functional near-infrared spectroscopy(fNIRS),to investigate the cortical functional connectivity(FC)alterations induced by AM-PAS.Methods:Totally,30 healthy right-handed volunteers were recruited and randomly assigned to either the AM-PAS or intermittent theta burst stimulation(iT-BS)group(n=15 each).Each participant underwent a single session of AM-PAS or iTBS targeting the left primary motor cortex(M1).Resting-state data were collected before and after the intervention.FC metrics were computed at the regional and hemispheric levels for within-group and between-group comparisons.In addition,the AM-PAS group underwent a separate intervention session during which motor evoked potentials(MEPs)were recorded at baseline and at 0,5,10,15,and 20 min post-stimulation to evaluate corticospinal excitability.Results:AM-PAS produced a progressive increase in MEP amplitude,with significant enhancement relative to baseline at 15 and 20 min post-stimulation(P＜0.05,0.01).In contrast to iTBS,which significantly strengthened whole-brain,inter-hemispheric,and interhemispheric connectivity(P＜0.05,0.01),AM-PAS induced a widespread reduction in corti-cal connectivity(P＜0.05,0.01).Between-group comparisons revealed significantly lower regional connectivity fol-lowing AM-PAS than iTBS,particularly within the left hemisphere(P＜0.05).Conclusion:AM-PAS effectively in-duces long-lasting enhancement of peripheral motor output for up to 20 min.Unlike iTBS,which promotes cortical coupling,AM-PAS triggers broad cortical desynchroni-zation,potentially reflecting the activation of subcorti-cal reticular circuits.These findings suggest that AM-PAS may complement existing neuromodulation tech-niques by engaging subcortical pathways,although its precise mechanisms warrant further investigation.