和解清热消积汤治疗小儿反复上呼吸道感染疗效及对临床症状改善、Th1/Th2免疫应答的影响OA
Effect of Hejie Qingre Xiaoji Decoction(和解清热消积汤)on Recurrent Upper Respiratory Tract Infection in Children and Its Influence on Clinical Symptom Improvement and Th1/Th2 Immune Response
目的 探究和解清热消积汤对小儿肺脾气虚夹热夹滞型反复上呼吸道感染的临床疗效.方法 选取2023年1月—2023年12月于医院儿科就诊的肺脾气虚夹热夹滞型反复上呼吸道感染患儿72例,采用随机分组法分为观察组及对照组各36例,其中对照组采用西药治疗,观察组在对照组基础上采用和解清热消积汤治疗,比较治疗1周后临床症状改善程度及不良反应,于治疗前及治疗1周后比较两组患儿中医证候积分、T淋巴细胞亚群水平[T淋巴细胞分化群3(Cluster of differentiation 3+,CD3+)、T 淋巴细胞分化群 4(Cluster of differentiation 4+,CD4+)、T 淋巴细胞分化群 8(Cluster of differentiation 8+,CD8+)、CD4+/CD8+]、免疫球蛋白[免疫球蛋白 A(Immunoglobulin A,IgA)、免疫球蛋白 M(Immunoglobulin M,IgM)、免疫球蛋白 G(Immunoglobulin G,IgG)]水平、Th1/Th2 免疫应答指标[白细胞介素-2(Inter-leukin-2,IL-2)、干扰素 γ(Interferon-gamma,IFN-γ)、白细胞介素-4(Interleukin-4,IL-4)、白细胞介素-10(Inter-leukin-10,IL-10)]水平差异变化.结果 治疗1周后,两组患儿临床症状改善时间、中医证候积分、CD8+、IL-4、IL-10水平显著低于同期对照组(P＜0.05);T淋巴细胞亚群(CD3+、CD4+、CD4+/CD8+)、免疫球蛋白、Th1/Th2免疫应答指标(IL-2、IFN-γ)水平明显高于同期对照组(P＜0.05).两组患儿均无明显不良反应.结论 和解清热消积汤能够有效调节肺脾气虚夹热夹滞型反复上呼吸道感染患儿机体免疫功能,增强机体免疫力,减轻其临床症状,加快疾病恢复进程,临床疗效良好.
Objective To explore the clinical efficacy of Hejie Qingre Xiaoji Decoction(和解清热消积汤)on children with recurrent upper respiratory tract infection of lung-spleen Qi deficiency and heat stagnation type.Methods Seventy-two children with recurrent upper respiratory tract infection of lung-spleen Qi deficiency and heat stagnation type who received treatment in department of pediatrics of the hospital were selected from January 2023 to December 2023,and were divided into observation group and control group by simple randomization method,with 36 cases in each group.The control group was treated with western medicine,whereas the observation group was given Hejie Qingfei Xiaoji Decoction on the basis of the control group.The improve-ment degrees of clinical symptoms and adverse reactions after 1 week of treatment and TCM syndromes scores,T lymphocyte sub-sets[cluster of differentiation 3+(CD3+),cluster of differentiation 4+(CD4+),cluster of differentiation 8+(CD8+),CD4+/CD8+],immunoglobulins[immunoglobulin A(IgA),immunoglobulin M(IgM),immunoglobulin G(IgG)]and Th1/Th2 immune response indicators[interleukin-2(IL-2),interferon-gamma(IFN-γ),interleukin-4(IL-4),interleukin-10(IL-10)]before treatment and after 1 week of treatment were compared between groups.Results After 1 week of treatment,the improvement times of clinical symptoms,TCM syndromes scores,the levels of CD8+,IL-4 and IL-10 in the two groups were significantly lower than those in control group(P＜0.05)while the levels of T lymphocyte subsets(CD3+,CD4+,CD4+/CD8+),immuno-globulins and Th1/Th2 immune response indicators(IL-2,IFN-γ)were significantly higher than those in control group(P＜0.05).There were no obvious adverse reactions in both groups.Conclusion Hejie Qingfei Xiaoji Decoction can effectively regu-late the body's immune function of children with recurrent upper respiratory tract infection of lung-spleen Qi deficiency and heat stagnation type,enhance the body's immunity,relieve the clinical symptoms and accelerate the disease recovery process,and it has good clinical efficacy.
张艳梅;闫永彬;王晓燕;鲁斌
河南中医药大学儿科医学院,河南郑州 450007郑州市中医院,河南郑州 450099河南中医药大学儿科医学院,河南郑州 450007河南中医药大学第一附属医院,河南郑州 450000
医药卫生
和解清热消积汤上呼吸道感染T淋巴细胞免疫球蛋白免疫应答
Hejie Qingre Xiaoji Decoction(和解清热消积汤)upper respiratory tract infectionT lymphocytesimmuno-globulinsimmune response
《中华中医药学刊》 2026 (1)
44-47,4
国家中医药管理局全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号)河南省中医药科学研究专项(2023ZY2148)
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