广州管圆线虫感染致病机制及研究进展OA
Research Progress on the Pathogenic Mechanisms and Prevention of Angiostrongylus cantonensis Infection
广州管圆线虫病是一种重要的严重危害人类健康的食源性人兽共患寄生虫病,其病原体是广州管圆线虫(AC).AC感染后,幼虫可穿过肠壁经肝脏、肺部移行至中枢神经系统,从而引起以嗜酸性粒细胞增多为特征的脑膜炎、脑炎、眼病以及肺炎等一系列疾病.深入了解AC对宿主组织的影响并揭示其相关致病分子机制,对于广州管圆线虫病的预防和治疗至关重要.故本文从多组学、病理学与免疫学等多个维度系统综述了近年来关于广州管圆线虫病感染、多器官致病及免疫调控相关机制,拟为该病精准诊断、临床防治及流行病学防控提供理论参考.
Angiostrongyliasis cantonensis is a major food-borne zoonotic parasitic disease caused by Angiostrongylus cantonensis(AC),representing a significant threat to human health.Upon infection,AC larvae penetrate the intestinal wall and migrate through the liver and lungs to the central nervous system(CNS).This process leads to various pathological conditions characterized by pronounced eosinophilia,most notably eosinophilic meningitis,encephalitis,ocular complications,and pneumonia.Elucidating the mechanisms of AC-induced tissue damage and its molecular pathogenesis is essential for the prevention and effective treatment of angiostrongyliasis.This review systematically synthesizes recent advances from multi-omics,pathology,and immunology to explore the mechanisms of infection,multi-organ pathogenesis,and host immune regulation.The goal is to provide a theoretical framework for enhancing diagnostic precision,optimizing clinical treatments,and strengthening epidemiological control of this disease.
孙希;吴忠道
中山大学中山医学院寄生虫学教研室//中山大学热带病防治研究教育部重点实验室,广东 广州 510080中山大学中山医学院寄生虫学教研室//中山大学热带病防治研究教育部重点实验室,广东 广州 510080
医药卫生
广州管圆线虫嗜酸性粒细胞性脑炎致病机制免疫调节多组学
Angiostrongylus cantonensiseosinophilia meningitispathogenesisimmunomodulationmulti-omics
《中山大学学报（医学科学版）》 2026 (1)
1-10,10
国家重点研发项目(2024YFC2309700)国家自然科学基金(82272361,82161160343),广东省自然科学基金(2024A1515010615),广东省重点研发项目(2022B1111030002)
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