中医药调节血管内皮细胞间质转化抗动脉粥样硬化研究进展OA

Endothelial-to-mesenchymal transition(EndMT)is a process in which endothelial cells lose specific markers and acquire a mesenchymal phenotype under pathological stimulation,contributing to the occurrence and progression of atherosclerosis(AS).Recent studies have shown that TCM,with its unique advantages of holism and treatment based on syndrome differentiation,can inhibit AS by regulating EndMT-related signaling pathways at multiple levels,through multiple pathways and targets.This article systematically reviews the mechanisms of EndMT in AS,as well as the research progress of TCM monomers and compounds in counteracting AS via EndMT intervention,providing new ideas and a scientific basis for the prevention and treatment of AS with TCM.