药物经鼻递送新技术及评价技术研究进展OA
Research progress on novel technologies and evaluation methods for nasal drug delivery
针对脑部疾病治疗的难题及鼻脑递送相关研究发展,对现阶段经鼻给药研究进展进行总结,提出多种药物鼻腔吸收新型评价模型.通过对离体动物组织模型、在体灌流模型、体内药动学模型、体外细胞模型、计算流体力学模型 5 种评价模型进行总结,阐明鼻腔给药相较于其他给药方式,有较为明显的优势;通过概述鼻腔给药新技术及刺激性评价,了解药物鼻脑递送的前沿方向,为后续鼻脑递送药物剂型选择提供必要支撑,为鼻腔给药发展开拓新的道路.
Focused on the challenges in brain disease treatment and advancements in nose-to-brain delivery research,this article summarized current progress in nasal drug delivery research and proposed several novel evaluation models for nasal drug absorption.By reviewing five types of evaluation models-ex vivo animal tissue models,in situ perfusion models,in vivo pharmacokinetic models,in vitro cell models,and computational fluid dynamics model-it clarified the distinct advantages of nasal drug delivery compared to other administration routes.Furthermore,by outlining emerging nasal drug delivery technologies and irritation evaluation methods,it explored the cutting-edge directions of nose-to-brain delivery.This provides essential support for the selection of nose-to-brain delivery dosage forms and paves new paths for the advancement of nasal drug delivery.
李琳;杜慧慧;刘彦洵;樊箫雨;叶津宏;沈慧娟;李鹏跃;杜守颖
北京中医药大学 中药学院,北京 102488北京中医药大学 中药学院,北京 102488北京中医药大学 中药学院,北京 102488北京中医药大学 中药学院,北京 102488北京中医药大学 中药学院,北京 102488北京中医药大学 中药学院,北京 102488北京中医药大学 中药学院,北京 102488北京中医药大学 中药学院,北京 102488
鼻腔给药药物吸收评价模型促鼻吸收新技术刺激性评价
nasal drug deliverydrug absorption evaluation modelsnovel nasal absorption enhancement technologiesirritation evaluation
《中国中药杂志》 2026 (1)
10-18,9
国家中医管理局高水平重点学科-中药药剂学项目(zyyzdxk-2023272)国家自然科学基金项目(82274111,81803738)
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